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Most of us are not strangers to the occasional scratchy, sore throat, an ailment that often heralds the onset of a common cold or a change in the weather. However, at times, what begins as a minor discomfort in the throat can evolve into symptoms that are more persistent and troubling. While many conditions could cause persistent sore throat, two common ones are tonsil stones and strep throat. Despite their distinct natures, both conditions share similar symptoms, like a sore throat, leading to a common dilemma in self-diagnosis. In this article, we aim to clearly differentiate between tonsil stones vs strep throat. We will explore the unique characteristics, causes, symptoms, and treatment methods for each condition.



What Is Tonsil Stones?

Tonsils are two round, fleshy masses at the back of your throat.

They are lymph nodes that filter germs that enter the nose and mouth.

Tonsil stones are small white-colored pebble-like stones that form in the tonsils. 

They are composed of minerals like calcium, food debris, and germs

Symptoms

Symptoms of tonsil stones and Strep throat infection can be very similar. 

Most people may experience the following symptoms:

Causes

Tonsil stones are formed when food debris gets stuck in the folds of the tonsils.

These folds are usually small, but when debris is trapped, it enlarges them.

This results in minerals like calcium getting deposited and hardening into stones.

Strep Throat

What Is It?

Strep throat is a contagious condition caused by a bacterial infection in the throat and tonsils. Strep throat is more common in children but affects people of all ages.

Symptoms

Common symptoms of strep throat are:

Some people may also experience nausea, vomiting, fatigue, and body aches.

Causes

Group A Streptococcus bacteria cause strep throat.

Tonsil Stones vs. Strep - The Differences

How Can You Easily Tell The Difference Between Strep And Tonsil Stones?

Since tonsil stones and Strep throat show similar symptoms, it is often difficult to tell one from the other. 

But, here’s how their symptoms are different, making diagnosis easy:

SymptomTonsil stonesStrep throat
Runny noseAbsentPresent
Sore throatPresentPresent but has a sudden onset
Bad breathPresentAbsent
CoughPresentMay not be present
Postnasal dripPresentAbsent
Stiff neckPresentAbsent
State of tonsilWhite or yellow small stones on tonsilsSwollen or red tonsil with streaks of white pus
Nausea and vomitingAbsentPresent

Do Tonsil Stones Always Mean Strep?

Recurring strep infection or tonsilitis can increase the risk of tonsil stones; but tonsil stones need not always mean that there's an underlying strep infection.

Are The White Spots In Strep Tonsil Stones?

No, not always. The white streaks or spots in strep are usually pus formations due to the infection, unlike the white ones in tonsil stones, which are hardened and calcified stones.

Diagnosis and Treatment: Tonsil Stones vs. Strep

Your doctor will perform a physical examination and check your nose, throat, and ear for signs of infection. 

If your doctor suspects strep throat, they will collect a swab from the back of your throat.

If you test negative for Streptococcus bacteria, a throat culture is performed to determine the causative organism of your tonsil stones.

The treatment for tonsil stones and strep throat varies.

Treatment of Tonsil Stones:

In many cases, tonsil stones are treated at home. Some common home remedies include:

Medications

Your doctor may prescribe antibiotics if required. Some OTC painkillers may also be helpful.**

Surgery

If tonsil stones keep recurring, your doctor may recommend tonsillectomy (a surgery to remove tonsils).

Treatment of Strep throat

Treating Strep throat usually involves a prescription of antibiotics.

Usually, amoxicillin or penicillin is prescribed to treat strep throat.

A single benzathine penicillin G shot is also used to treat strep throat.

Other antibiotics like erythromycin or cephalosporins like cephalexin may be prescribed to those who are allergic to penicillin.

It is important to treat strep throat at the earliest to prevent complications, which include:

Home remedies like gargling with salt water, getting plenty of rest, drinking warm fluids, and lozenges can help relieve sore throat associated with tonsil stones and strep throat.

Prevention: Tonsil Stones vs. Strep

Tonsil stones and Strep throat are contagious and can spread quickly.

You can prevent both conditions by practicing good hygiene, such as:

Summary

References

Alex, a seasoned construction worker, spends his days lifting and moving heavy materials. However, on a particularly strenuous day, while carrying a hefty piece of surveying equipment, Alex felt an unusual and disconcerting "popping" sensation in his lower abdomen. Concerned, he sought medical advice, and his fears were confirmed: Alex had developed a hernia. This diagnosis stirred a deeper anxiety within him. He recalled a pattern in his family—his father, uncle, and grandfather had all suffered from hernias. This familial recurrence led Alex to ponder a crucial question: Are hernias genetic? More importantly, Alex grappled with the concern that he might pass on the “hernia genes” to his own children.

In this article, we delve into the intricate relationship between hernias and genetics. We also aim to answer the pressing questions that linger in the minds of those who, like Alex, find themselves caught in a web of familial medical history.



What Are Hernias?

A hernia is a condition that occurs when organs or fatty tissue protrude through fragile areas in the surrounding muscle or fascia, similar to a bubble in a balloon.

These weak spots are common in areas like the abdomen or groin, and several factors can lead to their development.

Types Of Hernias

Not all hernias are the same. These bulges of organs happen in different places and have unique causes. Let's take a clear look at some common types of hernias:

What Causes Hernia?

Hernias happen when muscles get weak or strained. This can happen quickly or slowly.

Common causes:

Is There A Single Root Cause Of Hernias?

No, there is no single root cause for hernias. Their development is often a multifactorial process, meaning multiple factors contribute to their formation, with the two main contributors being:

Are Hernias Genetic?

Based on the reviewed studies, evidence suggests that groin hernias have a genetic component.

The research, which analyzed family histories and inheritance patterns, found that having a family history of inguinal hernia notably raises the risk of developing a primary hernia.

The studies also indicated a tendency for increased hernia recurrence rates and earlier recurrence when there is a family history of inguinal hernia.

What Types Of Hernias Are Genetic?

The current evidence focuses on groin hernias, but other types, like umbilical or hiatal hernias, might have different genetic influences.

More research is needed to understand the potential genetic link in other hernia types.

How Are Hernias Inherited?

According to a recent systematic review, the inheritance of groin hernias appears to have a notable familial component. However, there’s no clear inheritance pattern for hernias.

Studies on twins in children didn't always confirm a clear genetic link. Still, research on family histories and reliable databases revealed a higher risk of inguinal hernias in children with a family history.

Notably, there's a significant connection between mothers and daughters and between sisters, suggesting that the tendency to inherit hernias is stronger among females.

In adults, people with inguinal hernias were more likely to have a family history of the condition compared to those without hernias.

A nationwide study pointed out that the risk of getting surgery for an inguinal hernia was highest when a sister had already undergone the same surgery compared to a brother.

Also, having a sibling who had hernia surgery increased the chances of needing surgery for a femoral hernia.

However, the research indicates that having a family history is a significant factor in developing inguinal hernias, with a stronger inheritance pattern among females.

Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH) is an unusual condition that occurs in babies before birth.

It happens when the diaphragm, the muscle separating the chest and abdomen, doesn't close properly, creating a hole known as a hernia.

This opening allows abdominal organs like the intestines, stomach, and liver to move into the chest, affecting normal development.

The presence of intestines in the chest can lead to complications like malrotation, where the typical connections holding the intestines in place are disrupted.

This may cause twisting and cutting off of the blood supply (volvulus).

Additionally, the affected side's lung is smaller, and the development of both lungs is impacted.

The air sacs inside the lungs may not form correctly, leading to blood flow issues and increased pressure in lung blood vessels.

This higher pressure makes breathing challenging for the baby after birth, and some infants may also experience heart development problems.

Treatment for CDH depends on factors like when the condition is discovered, its severity, and whether there are associated heart issues.

What Are The Risk Factors For Genetic Hernias?

While hernias are often associated with increased physical strain or pressure, a subset can have a genetic component.

These "genetic hernias" are caused by mutations in specific genes that affect the proteins responsible for building and maintaining strong connective tissues, particularly collagen.

Beyond genes: Additional risk factors

Treating and Management

Hernias are usually fixed through surgery, especially if they're big or causing a lot of trouble. Here's what can be done:

Diagnosing and checking hernias:

Note: Remember, it's crucial to consult your doctor for personalized advice, whether considering surgery, using a supportive belt, or undergoing diagnostic tests.

Summary

Hernias, when organs bulge through weak spots in muscles, might have a family link, especially for groin hernias. 

If someone in your family had it, you might be at a higher risk. This connection is stronger among females.

While groin hernias seem connected to genes, we're still figuring out if other types, like belly button or upper stomach hernias, have the same link. 

Some gene mutations and family history can make you more prone to hernias.

Treatment involves surgery, lifestyle changes, and sometimes using a supportive belt. 

Regular check-ups and tests help keep an eye on things. Remember, talking to your doctor about your situation is crucial.

References

https://www.webmd.com/digestive-disorders/understanding-hernia-basics

https://my.clevelandclinic.org/health/diseases/15757-hernia

https://www.healthline.com/health/hernia

https://www.cdc.gov/copd/index.html

https://www.medicalnewstoday.com/articles/142334

https://pubmed.ncbi.nlm.nih.gov/23423330/

https://pubmed.ncbi.nlm.nih.gov/36443569/

https://www.mayoclinic.org/diseases-conditions/congenital-diaphragmatic-hernia/symptoms-causes/syc-20544249

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061067/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131122/

If there’s any food that can break the myth that plant sources don’t provide enough protein, it is definitely pumpkin seeds! They are also a great testament to the saying, “Good things come in small packages.” A small amount of pumpkin seeds eaten every day can enrich your body with magnesium, potassium, calcium, and zinc. Pumpkin seed powder is made by roasting pumpkin seeds, which increases its antioxidants due to heat exposure. It’s also touted to be one of the best plant protein alternatives for those who avoid animal or dairy-based proteins.


Did You Know?

Protein is one of the most important macronutrients for weight loss. It not only supports muscle mass building but also keeps you fuller for longer resulting in lesser calorie intake. However, not everyone may experience the same kind of weight loss with protein intake, with one of the most significant reasons being genetic makeup. Some genes interact with protein to influence its effect on the body.

At Xcode Life, you can upload your existing DNA raw data from ancestry genetic tests to understand how your body interacts with nutrients so that you can modify your diet to achieve your nutritional goals. Learn more.


What Is Pumpkin Seed Powder?

As the name suggests, pumpkin seed powder is obtained by grinding raw or roasted pumpkin seeds.

It has been found that pumpkin seed powder prepared from roasted pumpkin seeds has greater health benefits as roasting them increases the antioxidant content.

Roasting pumpkin seeds also improves their flavor and taste.

However, roasted pumpkin seeds may result in the loss of micronutrients.

Regardless of how you consume pumpkin seed powder, it is an excellent source of plant protein for vegetarians and vegans.

Is Pumpkin Protein Powder And Pumpkin Seed Powder The Same?

Pumpkin seed powder is prepared from 100% pure roasted or raw ground pumpkin seeds.

Pumpkin protein powder, on the contrary, contains pumpkin seed powder along with other plant proteins obtained from flaxseeds or quinoa. Therefore it is pumpkin flavored but does not contain 100% of pumpkin powder.

Always check the ingredient list to know if you are consuming pure pumpkin powder.

Sometimes, pumpkin protein powders contain whey or casein as the main protein source with pumpkin flavor.

Pumpkin seed powder and pumpkin seed protein are often the same product, provided the ingredient in both of them is pumpkin seeds.

How Much Protein Can You Get From Pumpkin Seed Powder?

One ounce of 28 g of pumpkin seed powder can give you 18 g of protein. Other nutrients you get from it are:

NutrientValue
Calories80
Carbohydrates1 g
Fat0 g
Sugar0 g
Calcium33 mg 
Iron6 mg
Potassium462 mg
Zinc7 mg
Magnesium319 mg

Other Nutritional Information

It also contains antioxidants like flavonoids and phenolic acid, and small amounts of vitamin E and carotenoids.

Benefits Of Pumpkin Seed Protein

There is ongoing research about the benefits of pumpkin seed protein.

Some of these include:

Researchers have found that pumpkin seed extract has anti-cancer effects on several cancers, including prostate, breast, lung, liver, and colon. 

This is attributed to the antioxidant properties of various phytochemicals present in it.

Pumpkin seeds contain oils that have been found to improve urinary symptoms. 

Some studies show that pumpkin seed extract improves prostate health.

However, more studies are required to prove this conclusively.

Many studies have stated that eating pumpkin seeds may help prevent depression. This is attributed to the amino acid tryptophan present in them.

Tryptophan is the precursor of serotonin.

Serotonin is the ‘feel good hormone’ and may have anti-depressant effects.

Several animal studies have found that pumpkin seed powder and extract have improved blood sugar levels.

This has been attributed to the protein, fiber, and fat content in the pumpkin powder.

Is Pumpkin Seed Or Pea Protein Better?

Pea protein and pumpkin seed protein are both protein-rich.

The question of ‘which is better’ depends upon your needs.

Pea protein is rich in proteins, whereas pumpkin seed powder is rich in fiber. 

Pumpkin seed protein is also rich in iron.

Pea protein and pumpkin seed powder have similar amino acid profiles, helping build muscle mass.

Consumption Guide

Pumpkin seed powder is versatile and can be used in multiple ways.

Are Pumpkin Seeds Healthy To Eat Everyday?

The American Heart Association (AHA) recommends you consume a quarter cup of pumpkin seeds (30 g) daily as part of a healthy diet.

This comprises protein, healthy fats, fiber, zinc, selenium, and magnesium.

How Much Pumpkin Seeds Should I Eat Daily?

While you can eat up to 30 g of pumpkin seeds daily as part of a healthy diet, it is always best to consult your dietician to determine the right quantity for you.

Is Pumpkin Seed Protein A Complete Protein?

Pumpkin seed protein contains all nine essential amino acids, similar to pea protein. 

However, it is low in threonine and lysine, making it an incomplete protein.

Does Pumpkin Seed Powder Protein Have Any Side Effects?

Side effects due to pumpkin and pumpkin seed powder are rare. 

However, some side effects may include:

A Few Ways To Incorporate Pumpkin Seed Powder To Your Diet

Pumpkin seed powder can be added to a variety of recipes.

Here are a few ways to do so:

Summary

References

Losing weight is a personal choice. It might be either because of serious health concerns or because one wants to look and feel good about themselves. Social media pages are full of fad diets and supplements that claim to reduce your weight miraculously. Some people claim that taking DHEA supplements has helped them reduce weight.
But is this true? 
Are there any side effects of taking DHEA supplements? Read on to find out.



What Is DHEA? 

Your adrenal glands located in your kidney produce a hormone called DHEA (dehydroepiandrosterone).

Scientists are not entirely sure what role DHEA plays in the body, but this hormone is a precursor to male and female sex hormones.

DHEA supplements are made from wild yam or soy.

Proponents claim that this supplement:

This supplement can be availed without a prescription.

How Are DHEA and Weight Loss Linked?

DHEA is known to block an enzyme named glucose-6-phosphate dehydrogenase, which is essential for fat synthesis. 

DHEA can also inactivate some enzymes related to fat synthesis.

Over time, this means that more fat is burned than produced.

DHEA and Abdominal Fat

A study was conducted on older men and women to find if DHEA reduced abdominal fat.

The subjects were divided into two groups.

One group was given DHEA supplements for six months, while the other did not.

After six months, the group that received DHEA showed a significant reduction in abdominal fat. 

But the results of this study do not automatically mean that you should buy DHEA supplements over the counter.

DHEA and Insulin Sensitivity

Insulin is a metabolic hormone that plays a crucial role in the body.

Insulin regulates blood glucose levels in the body.

The same study also showed that DHEA supplements could make people more sensitive to insulin and reduce resistance.

How Do Genes Interact With Nutrition To Influence Weight Loss?

Understanding how genes interact with nutrition is crucial for healthy and long-lasting weight loss.

Each person's genetic makeup is unique, and how our body responds to different nutrients in our diet can vary based on this genetic composition.

Expanding on the genetic response to specific nutrients and its influence on weight loss:

The interaction between genetics and dietary fats, particularly saturated fats, is a prime example of how our genetic makeup can influence weight management.

Genes And Fats

Saturated fats are found in foods like red meat, dairy products, and certain oils. The APOA2 gene is particularly noteworthy in this context. It plays a role in the body's handling of these fats.

People with specific variants of the APOA2 gene have been found to be more sensitive to saturated fats.

For these individuals, consuming a diet high in saturated fats can lead to a greater propensity for weight gain and accumulation of body fat, compared to those without this variant.

Essentially, their bodies respond to saturated fats in a way that promotes fat storage more than fat burning.

Genes And Carbs

Another example of how genetics can influence the body's response to specific nutrients, thereby affecting weight loss, involves the gene AMY1, which is responsible for the production of salivary amylase.

This enzyme is crucial for the breakdown of starches in our diet.

Individuals with more copies of the AMY1 gene produce more salivary amylase and are generally better equipped to break down starches efficiently.

On the other hand, those with fewer copies may find it harder to process these carbohydrates. This difference can significantly impact weight management.

For someone with fewer AMY1 copies, a diet high in starchy foods like bread, pasta, and potatoes might lead to more pronounced weight gain compared to someone with more copies of this gene.

Understanding these genetic predispositions allows for a more nuanced approach to nutrition and diet planning.

It's not just about the type of food consumed, but also how an individual's body processes these foods based on their genetic makeup.

This knowledge paves the way for personalized nutrition, offering tailored dietary recommendations that align with each person's unique genetic profile.

Other Effects of DHEA

Some proponents of DHEA supplements claim that they can reduce cervical cancer and heart disease risk. 

It can also reportedly treat sexual dysfunction.

However, these claims are yet to be proven.

DHEA For Anti-Aging

DHEA is a hormone whose secretion reduces with age.

Therefore, many scientists speculate that supplementing your body’s reduced DHEA levels can slow aging.

Some studies have shown that it has some effect on aging, while others have reported no effect.

There are also other health concerns to long-term DHEA usage.

DHEA For Other Health Conditions

DHEA has shown some promise in reducing mild depression in middle-aged and older adults.

The National Institute of Mental Health conducted a study that showed a reduction in mild to moderate depression in the elderly.

However, more research is required to back this claim.

Some scientists even claim that DHEA supplements can treat Alzheimer’s disease, Schizophrenia, and infertility. 

However, there is little evidence to support this claim.

DHEA For Weight Loss: What Are The Risks?

  1. Polycystic Ovarian Syndrome: Too much DHEA in the body can cause PCOS in women.
    Animals in the lab are often given DHEA to mimic symptoms of PCOS.
    Natural or as a supplement, too much DHEA can also cause a deepening of voice and overgrowth of body hair in females.
  1.  Irregular Menstrual Cycle: Since DHEA is a precursor for male and female sex hormones, taking it can raise their levels in the body. Raised estrogen levels in a woman’s body can disrupt the menstrual cycle.
  1. High Blood Pressure: DHEA supplements can also cause elevated blood pressure, insomnia, and nasal congestion.

Do You Need DHEA For Weight Loss?

DHEA and weight loss might be linked.

Some preliminary research has shown that DHEA does help in weight loss.

However, taking it might result in side effects.

Moreover, a proper diet and regular exercise are much more holistic approaches toward weight loss than consuming supplements. 

If you still want to check it out, consult your doctor before buying it over the counter.

Summary: DHEA And Weight Loss

DHEA is a hormone that is produced by your adrenal glands.

It is a precursor to male and female sex hormones.

This hormone decreases in the body with age.

Some people claim that DHEA supplements can contribute to weight loss and strengthen the immune system.

However, scientists still need to learn about the benefits of DHEA supplements, although some research shows that it is beneficial.

DHEA supplements might only be for some, as they may have side effects.

It is always advisable to consult your doctor before starting any supplements.

References

Despite the tremendous growth of the healthcare industry, some diseases like cancer remain elusive and hard to handle. Multiple factors contribute to the development and progression of the condition, gene variations being one of them. Genetic testing now makes it possible to know if a person is at risk for developing certain kinds of cancers. The 23andMe BRCA test can check DNA samples for 44 cancer-causing variants and help at-risk individuals take timely preventive actions. What is 23andMe’s BRCA accuracy rate? How much can these test results be trusted? What are the limitations of the test? Keep reading to know more. 


Contrary to popular belief, BRCA1 and BRCA2 genes don’t cause breast cancer. In fact, they have a protective role against cancers! In some cases, BRCA1 and BRCA2 genes have mutations that interfere with their protective role. Though these mutations may not definitely cause breast cancer, they do increase the chance for it to develop. Genetic tests can help find faulty genes and help family members find out whether they are at increased risk. Xcode Life looks for these mutations in your ancestry test DNA data and provides you with a comprehensive Breast Cancer Risk analysis. Learn more


23andMe BRCA 

Genetic testing can provide essential information about certain health risks, helping individuals take timely preventive actions.

23andMe is a personal genomics company that sells direct-to-consumer health and ancestry genetic testing kits. 

23andMe’s testing kits offer a combination of health predisposition, carrier status, wellness, pharmacogenetic, and ancestry reports, depending on the service chosen. 

The BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report is one such test report.

According to 23andMe, this test report may tell if a person has an increased risk of developing certain types of cancers due to BRCA gene variations.

23andMe BRCA Report Overview

The 23andMe BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report tests human DNA samples for 44 variants of the Breast Cancer 1 (BRCA1) and Breast Cancer 2 (BRCA2) genes.

The test uses human saliva samples for analysis. It may take up to a few weeks for the users to receive their test results digitally. 

BRCA1 And BRCA2 Genes

The BRCA1 and BRCA2 genes help create proteins that are tumor suppressors. 

These proteins also repair damaged DNAs and regulate cell division. 

According to the Centers for Disease Control and Prevention (CDC), 3% of breast and 10% of ovarian cancers are due to mutations in the BRCA1 and BRCA2 genes

Mutations in these genes affect both men and women and may also increase their risks of developing uterine, colon, stomach, pancreatic, and testicular cancers. 

How Accurate is the 23andMe BRCA Report?

According to the company’s website, all their health report tests, including the BRCA report, meet the Food and Drug Administration’s (FDA’s) analytical and clinical validity requirements. 

What does that mean?

The 23andMe BRCA report is the only FDA-authorized direct-to-consumer test for BRCA variants available in the market. 

However, the FDA specifies that the 23andMe BRCA report should not be used for diagnosis and cannot be used to make medical decisions. 

What does this mean?

It means that even if the BRCA report is >99% accurate, it cannot say if a person would or wouldn’t develop cancer.

Some people with the risk variants may not develop cancer, while those who don’t have the variants could end up with cancer due to other reasons. 

screenshot from 23andMe's BRCA report

Latest: FDA Clears 23andMe To Report On 44 BRCA Variants

The FDA protects public health by monitoring the efficacy and safety of food, drugs, cosmetics, biological products, and radiation-emitting electronics. 

The FDA assesses direct-to-consumer genetic tests for reliability, accuracy, clinical validity, and the truthfulness of their claims.

In 2018, the FDA authorized 23andMe’s initial BRCA genetic test.

This test analyzed and reported three variants of the BRCA1 and BRCA2 genes commonly found in people of Ashkenazi Jewish descent.

In August 2023, 23andMe received the FDA 501(k) clearance to test for 41 more variants in both these genes that may be associated with an increased risk of certain types of cancers.

Does This Mean 23andMe’s BRCA Report Is More Accurate?

Does the new FDA clearance mean the 23andMe BRCA accuracy rate has improved drastically? 

Since the BRCA test now reports on 44 variants instead of just 3, the chance of the test identifying a person’s risk of developing cancers has improved. 

This also means that the BRCA report would now be inclusive of people of different descents instead of just focusing on the Ashkenazi population. 

According to the company, this report may have the following ethnic accuracy rate.



Who Can Take 23andMe BRCA Report?

Any adult who can provide a saliva sample can take the 23andMe BRCA report.

Limitations Of 23andMe BRCA Report

  1. The 23andMe BRCA report is not a comprehensive genetic test option. About 4000 variants of the BRCA1 and BRCA2 genes may cause cancers, and 23andMe checks for only 44.
  2. This test may include only certain ethnicities and not the global population. 
  3. In rare cases, the 23andMe BRCA report may not be accurate and provide false positive or false negative results.
  4. The 23andMe BRCA report cannot precisely predict if a person will develop cancer. It only informs if the person is more likely to develop the condition.
  5. The report does not consider non-genetic factors that may affect cancer development. 

What To Do After You Get Your Results?

Once you receive the test results, you may find either of the three terms mentioned in the report. 

No Variant Found

This means none of the 44 variants tested were found in your DNA.

This, however, does not mean you have zero risks of developing cancers.

You may still have other cancer-causing variants not part of the test.

Non-genetic factors may also add to the risk.  

Variant Found

If one or more variants were found in your test report, you have a higher risk of developing certain types of cancers. 

The next step is to make an appointment with your healthcare provider and discuss the findings. 

Your doctor may have strategies to prevent or reduce your risk of developing these conditions. 

You can also speak to a genetic counselor to get more value from your test report. 

This is especially helpful if the findings make you uncomfortable, fearful, or anxious or if you are worried about the risk status of your relatives.

Sometimes, the counselor may advise your closest family members to get their genes tested to see if they carry the same variant. 

Result Not Determined

Random test errors, contaminated samples, or other external factors can prevent the lab from successfully analyzing your sample. 

In this case, the lab may ask for a new sample. 

Summary: 23andMe BRCA Report Accuracy

  1. The 23andMe BRCA1/BRCA2 (Selected Variants) Genetic Health Risk report analyzes a person’s risk for carrying one or more of the 44 variants that may increase the risk of developing different types of cancers.
  2. The BRCA1 and BRCA2 genes produce a protein that acts as a tumor suppressor. Variations in these genes may increase the risk of developing cancers.
  3. Up to 4000 such BRCA gene variations may cause cancer. However, this 23andMe test reports only 44 of these variations.
  4. On the brand’s website,  23andMe’s BRCA accuracy rate is > 99%. However, this is only relative to the reported 44 variants. 
  5. The 23andMe BRCA report is not comprehensive, as it tests for only some variants. Also, this test cannot predict if a person will develop cancer and can only tell if the person has an increased risk.
  6. After receiving the test report, talking to a genetic counselor and a healthcare practitioner would help take the right next steps. 

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010426/

https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/genes_hboc.htm

https://www.breastcancer.org/research-news/fda-authorizes-23andme-brca-genetic-test

https://www.fda.gov/medical-devices/in-vitro-diagnostics/direct-consumer-tests

AncestryDNA is the gold standard of genetic ancestry testing, giving you detailed information on your ancestral roots, along with some interesting tools to explore your ancestry. Follow this simple 3-step process to log in to your AncestryDNA account to access all this information.


Did you know that your AncestryDNA raw data contains around 700,000 genetic markers? Ancestry reports only use 0.01% of this information. There is more information about your health, nutrition, fitness, allergy, and specific genes like COMT, MTHFR, and APOE in your raw data. After finding out your ancestry information on the AncestryDNA site, you can download your raw data and use it to find out more about yourself. Learn how.


How to Login to Your Ancestry DNA Account

  1. Go to www.ancestry.com
  2. On the top-right-hand corner of your screen, click on “Sign in.”
  3. Enter your registered email address and password.

Forgot Your Password?

  1. If you do not remember your password, click on “Don't know your password?” near the sign-in button.
  2. You'll be prompted to enter the registered email address. Upon doing that, you will receive the link to reset your password.

How To Sign Out Of Your Ancestry DNA Account

  1. From any page on your account dashboard, click on your name or user name in the top-right-hand corner.
  2. From the drop-down menu, choose “Sign out.”

How To Download Your Ancestry DNA Raw Data?

  1. On the “DNA” tab, select “Your DNA Results Summary from the drop-down menu.
  2. Choose “Download your raw DNA data” from settings and click on “Get Started.”
  3. Enter your password.
  4. This will automatically trigger an email confirmation to the email ID linked to your AncestryDNA account.
  5. Upon clicking “Confirm data download” in the email, you will reach the download page on ancestrydna.com.
  6. The file will be downloaded to your system.

Or you can directly place a request to download your DNA data.


Discover 1000+ things about yourself with your AncestryDNA Raw Data


Other FAQs About Ancestry DNA Login

Why Can't I Log In To My Ancestry Account?

In case you are unable to access your AncestryDNA account, try the following:

  1. Ensure that you're signing in with the originally registered email address.
  2. Check for any typos in the email address/password.
  3. Clear your browser's history/cache, or use another browser (Ancestry recommends Chrome, Firefox, or Safari) to log in.
  4. If you are unable to log in to the app, try uninstalling and reinstalling it.
  5. If none of these work, you can contact AncestryDNA's customer support here.

How Do I Reactivate My Old Ancestry Account?

Most AncestryDNA accounts renew automatically at the beginning of each calendar month. Semi-annual and annual memberships renew every six months and year, respectively.

Do Ancestry Accounts Expire?

If your account doesn't renew automatically, then:

  1. Visit the Membership section on the Account settings page.
  2. If your account has an expiry date, you'll see a message saying, "Your membership is active currently and will end on the given date."
  3. You can also choose to renew your membership by clicking on the "Continue Membership" option and updating your billing information.

Can I Transfer My AncestryDNA Profile From My Old Account To My New One?

Your AncestryDNA results cannot be moved from one account to another. However, if you are the account owner, you can invite other people (or your new email) to view the results.

If you would like to share your ethnicity results, visit this page for the instructions.


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