Have you ever taken a genetic ancestry test with companies like 23andMe, AncestryDNA, FTDNA, MyHeritage? If you answered yes, it is likely that you have your DNA raw data with you! For those who do not know what DNA data is, when you take an ancestry test, most companies provide your DNA information in the form of a text file. This file is called the DNA raw data. You can download it directly from the company’s website or place a request through an email.
You can check out our DNA raw data download guides here:
DNA raw data from genealogical tests have around 700,000 genetic markers. Genetic markers are portions (sequences) of DNA with known locations. The portions of DNA close to each other are often passed down together. So, if the genetic marker is present close to a sequence that has known disease association, this marker can be used to identify and track the sequence of interest.
Genetic ancestry tests use these markers to track your lineage and provide ancestry and ethnicity reports - this is only a drop of water compared to the ocean of information you can get from your DNA raw data file.
There are both free and paid tools that can help you tap into this source to provide information on various topics like health, nutrition, and fitness. This article aims to provide you information on these tools to help you get started.
Free DNA Raw Data Exploration Tool
Xcode Life Gene Tool
Gene Tool is a free tool by Xcode Life that enables you to inspect your raw data files from Ancestry DNA, 23andMe, and My Heritage. Using this tool, you can easily find out the genotypes for specific rsIDs, search for gene names, and name of conditions that you may be interested in.
The most interesting part of the tool is that it provides you with a summary of your raw data: number of markers, chip type, and other basic information about your file.
There are many third-party tools and DNA upload sites that interpret your DNA raw data for you.
Some of the well-known DNA raw data analysis tools are Xcode Life, Genetic Genie, Stratagene, and GEDMatch.
Note: Most of these companies accept only genotyping raw data (like the ones from 23andMe and AncestryDNA). If you want to use your Whole-Genome sequencing data, you can head over to Xcode Life.
Other Than Ancestry Reports, What Information Can You Get From Your DNA Raw Data?
You can get information on various health and wellness aspects from your DNA raw data. Here are some commonly offered DTC (direct-to-consumer) genetic reports:
- Health Predisposition
- Cancer Risk
- Carrier Status Analysis
How to Read Your FTDNA, AncestryDNA, 23andMe Raw Data?
You do not need to read your 23andMe raw data by yourself. But, if you are curious, the raw data files have 4 columns of data that kind of looks like computer code.
The report providers translate this data into easy-to-read reports for you. You just have to upload your raw data and download your results.
There are companies like Xcode Life and others that specialize in providing you various reports based on your raw data from ancestry data providers such as 23andMe, AncestryDNA.com, or Family Tree DNA (FTDNA).
The best third-party tools or companies providing DNA raw data analysis services are listed below:
#1 on DNA Testing Choice
|Starting at $20||Nutrition, Health, BRCA1 and BRCA2, MTHFR, Carrier status, Precision Medicine, Fitness, Allergies|
|Genetic Genie||Free. Option for voluntary donation starting from $5.||Methylation and detox analysis|
|DNA Land||Free. The genome data will be used anonymously for research purposes.||Ancestry and lifestyle related traits.|
|GED Match||Mostly free. Premium tools are also provided.||Ancestry. Mainly for family matches using combined 23andMe, Ancestry DNA, Family Tree DNA database.|
|Nutrahacker||Ranges from $25 to $85.|
Free Detox Report
|Nutrient supplements, Detox, Carrier status, Depression, Fitness|
|Interpretome||Free||Ancestry and some heritable traits.|
|Genomelink||Free (limited traits)||Nutrition, personality, intelligence, physical, and sports traits|
|Dr. Ben Lynch's Strategene||$45||Health, Nutrition, Methylation and Detox analysis|
|Livewello||$20||Nutrition and Precision Medicine|
Xcode Life is a global genetics and bioinformatics company that specializes in analyzing DNA raw data files from various companies like 23andMe, AncestryDNA, FTDNA, MyHeritage, and LivingDNA.
Xcode Life also accepts whole-genome files from companies like Nebula Genomics and Dante Labs.
Xcode provides a variety of expertly curated reports, starting at $10, including 23andMe health reports, nutrition, medication sensitivity (precision medicine), fitness, allergy, skin, personality, sleep, and other custom reports.
Xcode Life Reports List
- Nutrition report
- Fitness report
- Health report
- Allergy report
- Skin report
- Carrier Status report
- Breast Cancer and BRCA report
- Methylation and MTHFR report
- Personalized Medicine report
- Gene Sleep Report
- American College of Medical Genetics & Genomics (ACMG)
- Traits and Personality report
- COVID-19 Genetic Analysis
These reports come with a specific recommendation for people with your genetic type, all of which are delivered in under a couple of hours.
Moreover, counseling is also available upon request.
In addition, Xcode Life also provides reports to individuals and professional practitioners such as physicians, surgeons, nutritionists, sports trainers, chiropractic, and other professionals.
Get your 23andMe raw data analyzed here.
Promethease - Now acquired by MyHeritage
Promethease is a software program that was developed by SNPedia to perform raw data analysis.
It uses your 23andMe raw data to generate disease-based reports.
They charge $12 per report.
However, it is to be noted that they may be quite technical for most people unless they have expert knowledge of polymorphisms and biostatistics.
This literature retrieval system analyzes your 23andMe, FTDNA, or AncestryDNA raw data and then builds a report based on the vast SNPedia database.
The reports contain information about health, precision medicine as well as some other traits.
The report gives you health information regarding your genetic risks for certain illnesses such as Alzheimer's.
In spite of its popularity, the scientific rigor of Promethease is often questioned due to its reliance on SNPedia, a Wikipedia-like repository of scientific literature.
Update: In 2019, MyHeritage acquired Promethease and SNPedia.
MyHeritage offered Promethease free of charge through the end of 2019 and continues to maintain SNPedia as a free resource for academic and non-profit users.
For Non-European users, the DNA raw data will be shifted to MyHeritage into new accounts, which will be created for them.
However, the users will retain the ownership of their DNA raw data file and are free to delete it from MyHeritage's server.
Athletigen 23andMe Raw Data Analysis
As the name indicates, Athletigen does “athletic profiling” of the 23andMe raw data analysis.
They accept 23andMe and AncestryDNA raw data but also offer their own kit, which costs $174.99 and includes the Welcome report ($59.99).
They offer Nutrition Report ($69.99), Athletic Report ($64.99), Wellness Report ($59.99), ALTIS Sports Performance Report ($79.99), and Optimum Movement and Recovery Report ($79.99).
It seems to be unclear whether Athletigen is currently used by many people, as there have been no recent reviews about the company.
Genetic Genie 23andMe MTHFR Raw Data Analysis
Genetic genie provides free methylation and detox reports.
This tool uses your DNA raw data from companies like 23andMe and AncestryDNA to perform methylation analysis.
The site also provides a tool for a detox analysis that looks for defects in the cytochrome P450 detox enzymes.
Incorrect methylation leads to a wide range of serious medical conditions.
This makes the methylation profile offered by genetic genie a good report.
The detox profile looks at gene single nucleotide polymorphisms (SNPs) of the cytochrome P450 detox enzymes.
The methylation report is detailed, but the detox report just displays a table without any interpretation.
This is a free service, but a voluntary donation starting from $5 is accepted.
Livewello Raw Data Analysis
Livewello accepts raw data files from 23andMe, AncestryDNA, Family Tree DNA, and Gene By Gene.
After paying a one-time fee of $20, you get to keep your account for life.
A monthly subscription of $5.95 or a yearly subscription of $60 allows access to the Livewello app.
Livewello offers 20 reports. Some of them include:
- Warfarin sensitivity
- Hepatitis C treatment
- Preference for sweet foods
- Vitamin B12
- Alcohol tolerance
The New StrateGene Analysis
With the new StrateGene, you can no longer upload your DNA raw data files from 23andMe.
Their DNA kit is priced at $295, and you can choose between a tube kit (saliva sample) and a swab kit (cheek swab sample).
You'll receive the following:
- A DNA kit
- StrateGene Core Report – Digital
- StrateGene Raw Data – Digital - for browsing and downloading your raw data
- Dirty Genes by Dr. Ben Lynch – Physical Book
- Dirty Genes Course – Digital
- Dirty Genes Summit (2 Interviews) – Digital
- ABC's of Clean Genes – Digital
The users seem to find the reports a bit too complex to be of real use. So, this may not be the right choice for those who would prefer easily understandable results and readily implementable recommendations.
Enlis Genomics 23andMe Raw Data Analysis
This 23andMe raw data analysis service provider is more for educational purposes and not for direct consumer purposes.
Their service, which caters to research scientists, focuses on analyzing DNA data to provide users with information about the health risks associated with specific genetic variants.
The initial intention of developing this software is to allow researchers to analyze full genome files, but they have then added a software program for personal use and a free genome report accessible directly from their site.
Genomelink Raw Data Analysis
Genomelink lets users upload raw DNA data from 23andMe, Ancestry, or MyHeritage. Users can also let the site connect directly to their 23andMe or Ancestry account to retrieve their DNA data.
Users who upload the DNA data will immediately receive 25 trait reports free of charge.
To unlock more traits, you have to be subscribed to their ‘Unlimited Plan’ for $14/month, which may not really be cost-effective
After signing up, all your reports will be consolidated and present in your dashboard, which can be accessed only online, as downloadable PDF reports are not available.
A feedback option will be present next to every trait in your dashboard, so you can choose to let them know whether or not the results provided are accurate.
While the interface is pleasing, their reports are not extensive and cover only a little over 100 traits.
This is relatively small compared to other companies that provide over 300 traits.
In addition to the regular trait reports, they offer three reporting packages: Ancient Ancestry Report ($29), Personalized Nutrition Advice ($24), and Personalized Fitness Report ($39).
NutraHacker Raw Data Analysis
Nutrahacker accepts DNA raw data files from 23andMe, AncestryDNA, tellmeGen, or MyHeritage.
Once you upload your DNA raw data, you'll be required to fill out a questionnaire and submit your email address.
You will receive a free copy of COVID report and Detox report.
Additionally, you can purchase the following reports:
- Celiac report - $20
- Complete mutation report - $37
- Depression report - $85
- Fitness report - $55
Interpretome, now named GENOtation, has 12 publicly available genotype files for education/research purposes.
It also has SNP and genotype information for the following traits:
DNAFit Raw Data Analysis
DNAFit lets you upload your data from 23andMe or buy their kit. They offer the following reports:
- Diet Fit - £104.30
- Health Fit - £139.30
- Circle Premium - £349.30
The report is available online. Initially, the information does feel a bit overwhelming.
However, the reports do a good job of giving background information relevant to the results.
This is fairly comprehensive and includes a list of the genes analyzed in the test, along with information about each gene.
If you are a hardcore athlete, you might want to consider this. However, before buying, do check out our comparative blog on the top 5 fitness DNA fitness report providers.
Lifenome Raw Data Analysis
Lifenome accepts DNA raw data files from 23andMe, AncestryDNA, and FamilyTreeDNA. They offer the following products:
- COVID-19 Spare - Determine Risk of Severity
- XHealth Precision Health and Wellbeing Platform - Nutrition & Diet Programs, Fitness Programs, Sleep & Stress Management
- Genetic Predisposition Assessments - Nutrition & Diet Reports, Allergy and Sensitivity Reports, Beauty Reports, Fitness Reports
- Precision Consumption Ecosystem
Other Resources to Explore More
Here are some resources that will give you more information:
- List of the most popular genetic testing companies: ISOGG Wiki
- There are some good answers to a Quora question along similar lines: https://www.quora.com/Which-tools-can-be-used-to-analyze-23andMe-raw-data
Updated on June 01, 2021