Did you know that not all natural supplements are as safe as they seem? While some can offer health benefits, others might harm your liver, the most vital organ responsible for cleansing your body. NIH research has revealed that liver injury induced by herbal and dietary supplements (HDS) accounts for 20% of hepatotoxicity cases in the United States. This means being cautious about your supplements, which is crucial for safeguarding your liver health. Keep reading to explore 7 natural supplements that may cause liver damage, either directly or through interactions with other medications. Additionally, we'll address liver damage signs, delve into liver-stressing vitamins, and provide practical supplement selection tips for liver health maintenance.

7 Natural Supplements That Cause Liver Damage

While many turn to natural supplements for improved health, some contain unexpected downsides.

It's important to be aware of potential side effects, especially those impacting the vital liver.

Here are 7 commonly used supplements that, under certain circumstances, can harm your liver:

1. Kava: This Pacific Island drink provides relaxation but can cause liver injury or failure, especially in those with pre-existing liver issues or taking medications.
2. Green tea extract: Packed with beneficial antioxidants, this concentrated form can have a dark side. High doses or underlying liver issues can lead to liver toxicity, jaundice, and even failure.
3. Comfrey: This plant might seem helpful for wounds, but it hides harmful chemicals called pyrrolizidine alkaloids. These can seriously damage your liver, blocking vital veins and potentially leading to failure.
4. Chaparral: While some use it for health reasons, this plant contains nordihydroguaiaretic acid, a toxic chemical. It can cause liver inflammation, hepatitis infection, and even failure in some individuals.
5. Aloe vera: Known for its calming properties on the skin, aloe vera juice or gel taken internally can have unexpected consequences. Liver toxicity, hepatitis, and even failure have been reported, especially in high doses or with pre-existing liver issues.
6. Black cohosh: Although helpful for managing menopausal symptoms, black cohosh contains triterpene glycosides that can affect the liver. This can lead to hepatitis, jaundice, and even liver failure in some individuals.
7. Echinacea: While this popular immune booster aims to fight infections, it can have its own battle with the liver. Liver toxicity, hepatitis, and even failure have been reported, particularly in high doses or individuals with autoimmune diseases or liver disorders.

Do Natural Supplements Cause Hepatotoxicity?

As mentioned earlier, herbal and dietary supplements contribute to 20% of hepatotoxicity cases in the US.

The research found significant culprits like anabolic steroids, green tea extract, and multi-ingredient nutritional supplements (MINS) as common causes.

Anabolic steroids, often sold as bodybuilding supplements, usually result in a prolonged cholestatic liver injury. A specific pattern in blood tests and liver tissue samples characterizes this type of injury.

On the flip side, green tea extract and similar products are prone to trigger acute liver injury, with symptoms closely mirroring those of hepatitis.

However, the majority of HDS-associated liver injuries are linked to MINS, where the specific toxic component is often unknown.

This poses challenges in diagnosis, treatment, and prevention. Improved regulatory oversight is crucial to ensure the purity and safety of non-prescription products.

Collaboration among healthcare professionals, chemists, and toxicologists is essential to identifying and regulating harmful ingredients and promoting public safety.

Symptoms Of Liver Damage

Symptoms indicating potential liver function issues can appear in various ways.

Other symptoms include:

• Fever
• Itching
• Yellowing of the eyes or skin (jaundice)
• Lower legs, ankles, or feet swelling (edema)
• Nausea
• Vomiting
• White or gray stool

These indications could appear rapidly or gradually, depending on the cause and severity of liver injury.

It is vital to consult a physician promptly if you notice any of these signs so they can evaluate the condition and provide necessary treatment.

What Vitamins Are Hard On The Liver?

Vitamin A and niacin (vitamin B3) are the vitamins that are hard on the liver in high doses.

While most vitamins, when taken within recommended amounts, rarely cause liver harm, vitamin A and niacin can lead to distinctive forms of liver injury.

This risk arises because many vitamins, especially fat-soluble ones, are concentrated, metabolized, and stored in the liver.

Exceeding safe intake levels can overload the liver's capacity to process these vitamins, resulting in liver damage.

Thus, caution should be exercised with vitamin A and niacin supplementation to prevent liver injury.

Tips To Keep Your Liver Healthy

While some supplements may be effective in supporting liver health, it is important to talk to your doctor about it and only take those that are prescribed.

• Consult your doctor: Before considering any herbal product, discuss it with your doctor. They can provide insights into potential risks and interactions with other medications.
• Avoid risky supplements: Be cautious with supplements containing multiple herbs or unfamiliar ingredients. Some, like green tea extract or anabolic steroids, can harm your liver.
• Research ingredients: Look up the ingredients of herbal remedies before using them. Certain herbs, such as milk thistle, may benefit liver health, but others, like comfrey or kava, can cause damage.
• Check LiverTox: Visit the LiverTox website to learn about supplements that may harm your liver. This resource provides information on ingredients known to cause liver injury.
• Choose certified supplements: Opt for supplements tested by independent labs like ConsumerLab or NSF International to ensure purity and safety.
• Inform your doctor: Report all supplements to your doctor to avoid potential interactions with prescription medications, especially if you have liver issues.
• Limit supplement use: Take herbal products according to the recommended dosage and prioritize maintaining a balanced diet and lifestyle to promote overall liver health.

Summary: 7 Natural Supplements That Cause Liver Damage

Be careful with some natural supplements, as they can hurt your liver.

Be cautious with kava, green tea extract, comfrey, chaparral, aloe vera, black cohosh, and echinacea supplements, especially if you have liver issues or take other medications.

Watch for signs like tiredness, yellow skin, or belly pain, which could mean liver damage.

Too much vitamin A and niacin can harm your liver. Before starting any new supplements, consult your doctor first.

Check what's inside them and pick brands that have been properly tested and approved.

Eating healthy foods and living a good lifestyle is best for keeping your liver healthy. Only use supplements when you really need them.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502701/

https://www.ncbi.nlm.nih.gov/books/NBK548637/

https://www.ncbi.nlm.nih.gov/books/NBK547925/

https://www.ncbi.nlm.nih.gov/books/NBK548370/

https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/larrea

https://www.ncbi.nlm.nih.gov/books/NBK547990/

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/triterpene-glycosides

https://www.ncbi.nlm.nih.gov/books/NBK548440/

https://www.webmd.com/hepatitis/toxic-liver-disease

https://www.ncbi.nlm.nih.gov/books/NBK548888/

https://www.everydayhealth.com/news/toxic-not-healthy-surprising-liver-dangers-herbal-products/

Imagine this: You've been regularly going to the gym, pushing yourself, and attempting to gain lean muscle mass. Along the way, you've heard about the advantages of using creatine supplements, including

• Increased strength
• Improved performance
• Faster muscle recovery 

Excited to try it out, you dive into the world of creatine, only to be met with concerns about bloating. But does creatine make you bloated?

Let's unravel the truth behind this common question and explore effective strategies to minimize any potential bloating.

What Is Creatine?

Creatine, an amino acid found in our muscles, is a powerful energy generator during high-intensity exercise. 

Its primary role is to help regenerate ATP (Adenosine Triphosphate), the body's major energy source, allowing you to perform at your best throughout heavy workouts. 

This amino acid is available in various forms:

• Powders
• Tablets
• Capsules
• Liquids

You can also consume it by taking creatine-rich foods, such as:

• Red meat
• Seafood
• Animal milk

Benefits of Taking Creatine

Creatine supplementation can improve athletic performance and has several benefits, including:

• Increased muscle strength and power: Research has shown that taking creatine supplements can help people lift heavier weights and perform explosive movements more easily, ultimately improving their overall performance.
• Improved exercise performance: Creatine can boost muscle energy, improve stamina during workouts, and help individuals take on more challenging exercises.
• Enhanced muscle growth: Regular use of creatine promotes protein synthesis, which helps repair and build muscles. This leads to a more toned and defined physique.
• Faster muscle recovery: It has been shown that creatine reduces muscle damage and inflammation, enabling quicker recovery after workouts and lowering the risk of overtraining.
• Potential cognitive benefits: According to some studie­s, taking creatine suppleme­nts may help improve cognitive abilitie­s such as memory and intelligence­; however, these­ findings require further re­search to validate them.
• Medical applications: Creatine has been exemplified in treating medical conditions like Parkinson's disease, muscle disorders, and depression, though more research is needed to confirm its effectiveness. 

Does Creatine Make You Bloated?

Now, onto the burning question – does creatine make you bloated? 

A phenomenon known as creatine bloating can often occur while adopting creatine supplements, especially during the early loading phase. 

Taking a more significant dose of creatine, usually 20–25 grams, to saturate the muscles is required during this period, which lasts for about 5-7 days on average. 

Temporary bloating may result at this time due to an increase in creatine intake and increased water consumption.

Thus, it is important to note the bloating felt during the loading period is temporary and usually goes away within a few weeks. 

This is not the same as bloating caused by digestive issues or excess gas.

Creatine Water Retention

Creatine helps generate energy by increasing the concentration of creatine phosphate in the muscles. 

As a result, the muscles hold onto extra water, which helps rise in body weight.

It's important to understand that this water retention is intramuscular, meaning it stays within the muscle cells and not in the spaces between cells or organs.

How Does Creatine Bloating Feel?

The water retention associated with creatine usage may make you feel slightly heavier or fuller, but it is not the same as bloating caused by digestive problems. 

True bloating often involves discomfort, distention, and excessive gas. 

With creatine-related water retention, you may notice a subtle increase in body weight and muscle fullness, but it should not cause significant discomfort.

How Long Does Creatine Bloating Last?

Creatine bloating is temporary and should stop within a few days to a couple of weeks - this can be avoided by taking a lower dosage.

Did You Know?

Your genes influence important aspects of fitness like your endurance potential, injury risk, premature fatigue, motivation to work out, etc. Unlocking this information using your ancestry test DNA data can help you achieve your fitness goals seamlessly.

Who Does Creatine Work The Best For?

Creatine significantly influences people who engage in high-intensity, short-duration activities.

For example, weightlifting, running, and boxing athletes often see a significant performance boost with creatine supplementation. 

However, even if you are not a top athlete, creatine can enhance your fitness journey by helping you gain strength, stamina, and total muscle development.

Who Should Not Take Creatine?

While creatine is usually safe for most people, certain groups should use caution or avoid supplementation. 

For example, individuals with kidney disease, high blood pressure, liver disease, or a history of kidney stones shouldn’t use creatine.

If you are breastfeeding or pregnant, it is advisable to avoid creatine.

Making informed decisions about supplements and prioritizing your health is important.

How Do You Fix Bloating From Creatine?

If you experience water retention or perceived bloating from creatine, there are effective strategies to minimize these effects:

• Stay hydrated: Drinking plenty of water during the day is important for reducing the risk of bloating and supporting healthy muscles. Aim for an additional 8-16 ounces (240-480 ml) of water when supplementing with creatine.*
• Consider creatine monohydrate: According to several studies, creatine monohydrate is safe and effective for reducing water retention. On the other hand, ethyl ester and buffered creatine could not provide the same advantages or have sufficient evidence to support their use.**
• Skipping the loading phase: Another strategy is to skip the loading period and begin with a maintenance dose of 3-5 grams of creatine daily to reduce or prevent bloating.

Will Creatine Bloat Go Away?

Yes, the water retention associated with creatine usage will gradually subside once you stop taking the supplement. 

However, it's important to remember that this temporary water weight is unrelated to body fat or actual bloating, and it should not be a cause for long-term concern. 

If you discontinue creatine, your body's water balance will normalize.

How Much Water Should I Drink With Creatine?

Aim to consume an additional 8-16 ounces (240-480 ml) of water daily to support the benefits of creatine supplementation and maintain maximum hydration.* 

This helps to flush out waste products, support muscle function, and promote overall well-being. 

Remember, hydration is key to unlocking your full fitness potential.

The Best Creatine Supplement Form To Prevent Bloating

If you're concerned about water retention and potential bloating, stick with creatine monohydrate.** 

This form of creatine is widely recognized as safe and effective, with numerous scientific studies backing its benefits.

Avoid experimental or lesser-known forms of creatine that lack sufficient evidence or may have undesirable side effects. 

By choosing creatine monohydrate from a reputable brand, you can maximize the advantages of creatine while minimizing any temporary water retention.

*overhydration can also lead to digestive issues like nausea or vomiting. 

**Please consult a doctor for advice on the best supplement for your body’s needs

Summary: Does Creatine Make You Bloated?

Taking creatine can cause temporary muscle hydration that leads to bloating, but it's not permanent. When you stop taking creatine, the bloating will disappear, and your body will return to normal rather than digestive issues or excess gas.

By following a balanced diet, and selecting a reputable creatine monohydrate supplement, you can enjoy the benefits of creatine while minimizing any temporary water weight.

Before beginning creatine supplementation, seek advice from a healthcare professional to ensure it suits your needs and health status, just like any other dietary supplement.

References

• https://www.healthline.com/nutrition/creatine-bloating/
• https://my.clevelandclinic.org/health/treatments/17674-creatine/
• https://www.medicalnewstoday.com/articles/263269

Did you know that your body cannot produce zinc on its own? You must either acquire it through food or supplements. While zinc is necessary for proper bodily functions, excessive consumption can have potential side effects, too. This article explores one such side effect, answering one of the commonly asked questions about zinc supplementation - can zinc make you nauseous? 

Zinc: An Overview

Zinc is a crucial trace mineral required for overall health. Each cell in the body has it and supports various bodily functions. 

Role Of Zinc In The Body

Now that we understand zinc let's explore its crucial functions within the body.

• Supports immune system health.
• Regulates 300 enzymes in the body (e.g., alkaline phosphate).
• Monitors cell division and growth.
• Plays an antioxidant role that protects cells from oxidative damage produced by free radicals.
• Helps maintain good vision - by playing a role in vitamin A metabolism.
• Maintains a healthy sense of taste and smell.
• Creates and releases hormones like insulin, testosterone, and growth hormone.

Zinc Deficiency: Causes and Symptoms

When a person does not consume or absorb enough zinc, it can lead to a deficiency of this mineral in the body, known as zinc shortage. 

It is estimated that over 2 billion people worldwide are zinc deficient due to a poor diet.

Although severe zinc insufficiency is not common, some groups of people are more prone to it.

• Nursing infants whose mothers are deficient in zinc.
• Those with alcohol addictions.
• People who use certain immune-suppressing medicines.
• People on long-term limited diets - vegetarians and vegans
• Babies exclusively breastfed for more than six months and children on restricted diets

Some symptoms of zinc deficiency include:

• Hair loss
• Eye problems
• Changes in their nails
• Feeling irritable
• Diarrhea
• Impotence
• Weight loss
• Wounds that take a long time to heal
• Lack of taste and smell

Can Zinc Make You Nauseous?

Yes, high zinc consumption can occasionally cause nausea. 

While zinc is a necessary mineral, overeating can produce gastrointestinal symptoms such as nausea, vomiting, and stomach cramps.

A balanced diet can meet most people's zinc requirements. 

If zinc supplementation is necessary, it should only be done under the guidance of a healthcare professional to prevent overdosing and any negative consequences.

Why Do I Get Nauseous After Taking Zinc?

Nausea after taking zinc supplements can occur due to various reasons.

• Digestive disturbances: The stomach lining may become irritated when zinc is consumed on an empty stomach, leading to gastrointestinal discomfort and nausea.
• Higher dosages: Exceeding the recommended dosage of zinc can overload the body's ability to process it, resulting in gastrointestinal symptoms.
• Individual sensitivity: Some individuals may be more prone to nausea from zinc supplementation, even at recommended dosages, due to a sensitive stomach or underlying gastrointestinal issues.

How Do You Stop Nausea When Taking Zinc?

To stop nausea when taking zinc, you can follow these key steps:

• Take zinc with food and juice to reduce the risk of nausea.
• Avoid taking it before exercising.
• Stick to the recommended dosage to avoid overwhelming the body.
• Consider gradually increasing zinc intake if nausea persists.
• Consult a healthcare professional for personalized guidance.

Implementing these measures can effectively address and reduce nausea associated with zinc supplementation.

How Quickly Can Zinc Make You Nauseous?

The time it takes for nausea to occur after taking zinc may differ from person to person.

In some cases, nausea may occur relatively quickly after consuming zinc supplements, while in others, it may take some time.

Factors such as individual sensitivity, dosage, and whether zinc is taken on an empty stomach can influence how quickly nausea develops. 

Paying attention to your body's response and monitoring any symptoms after taking zinc is essential.

If you experience nausea consistently or severely shortly after consuming zinc, it is important to adjust the dosage, take it with food, or consult a healthcare professional for further guidance.

How Long Does Nausea From Zinc Last

Other than nausea, an overdose of zinc can also result in diarrhea, stomach pain, and vomiting, which may start within 3-10 hours of exposure and resolve after 12-24 hours of stopping the supplementation.

RDA Of Zinc: How Much Zinc Do You Actually Need?

Zinc's Recommended Dietary Allowance (RDA) varies according to age, gender, and life stage. The RDA values for various groups are as follows:

Did You Know?

Your genes influence how much your body absorbs and utilizes zinc from food. Certain gene changes can increase your risk for zinc deficiency. You can use your ancestry genetic test DNA data to learn in-depth about your entire nutritional profile, including vitamin deficiencies, food intolerances, and the ideal diet for your body type. Learn More.

Zinc Supplements: An Overview

Many people, with good reason, turn to zinc lozenges and tablets when they are sick. It is one of the body's most abundant trace minerals, essential to every health aspect.

A person can also try to consume more zinc-containing foods, such as:

• Oysters
• Baked beans
• Yogurt
• Beef
• Chickpeas
• Instant, plain oatmeal
• Fortified breakfast cereals
• Milk

Types Of Zinc Supplements

Many different zinc supplements are available in the market, each with unique effects on your health.

Here are some of the most commonly found options:

• Zinc gluconate: Widely accessible and available over the counter, zinc gluconate is commonly found in cold remedies like tablets and nasal sprays. It is often used to reduce cold symptoms.
• Zinc acetate: Zinc acetate, similar to zinc gluconate, is often included in cold tablets to reduce symptoms and promote faster recovery.
• Zinc sulfate: Besides preventing zinc deficiency, zinc sulfate can reduce the severity of acne.
• Zinc picolinate: Rese­arch shows that zinc picolinate may enhance zinc absorption more­ effectively than othe­r forms, such as zinc gluconate and zinc citrate.
• Zinc citrate: Zinc citrate absorbs just as well as zinc gluconate but has a more pleasant taste and less bitterness.

Zinc suppleme­nts come in different forms, such as capsule­s, tablets, and lozenges. One can decide as per their daily requirements for zinc.

It's important to note that using nasal sprays containing zinc may result in a potential loss of smell; therefore, consult a doctor before using them.

Side Effects Of Zinc

Consuming 150 to 450 mg per day of excessive zinc can result in additional side effects. Here are some of them:

• Low copper levels
• Changes in iron function
• Reduced immune function
• Reduced levels of "good" cholesterol
• Urogenital problems

Can Zinc Upset Your Stomach?

Yes, zinc can upset your stomach if not taken correctly. Taking zinc on an empty stomach can trigger nausea and upset stomach. Consuming too much zinc or getting it from the wrong sources can also cause nausea.

How To Safely Consume Zinc?

For safe and effective consumption of zinc, it is important to follow certain guidelines. Such as:

• Choose recognized brands and all sources for using supplements to assure product quality and accuracy.
• Prioritize getting zinc from a healthy diet with zinc-rich foods, including meat, seafood, legumes, nuts, seeds, and whole grains.
• Consider your total zinc intake from supplements and dietary sources.
• If you use medications, check with your doctor to be sure there are no potential conflicts between the prescriptions and zinc supplements.

Summary: Can Zinc Make You Nauseous?

Zinc is an important trace mineral that is needed for maintaining optimal health.

Although it has many advantages, excessive intake may have side effects. One side effect of taking zinc in excessive dosages or on an empty stomach is nausea.

It's crucial to follow dose recommendations, take zinc with meals, and, if required, seek medical advice.

Low copper levels, changes in iron function, decreased immunological function, lower amounts of "good" cholesterol, and urogenital issues are other potential adverse effects of excessive zinc use.

References

https://www.medicalnewstoday.com/articles/263176

https://www.healthline.com/nutrition/zinc-supplements

https://www.healthline.com/nutrition/zinc

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396684/

https://pubmed.ncbi.nlm.nih.gov/3630857/

https://pubmed.ncbi.nlm.nih.gov/2407097/

https://pubmed.ncbi.nlm.nih.gov/12026029/

In a world where technology continuously pushes the boundaries of what we once thought was possible, DNA testing has evolved into a fascinating way of self-discovery. It is important to conduct detailed research before choosing a DNA testing company that aligns with your preferences. CriGenetics and 23andMe are two famous players in this field. They both offer DNA testing services and promise to reveal secrets buried in our genetic code. 

For better clarification, we have compared these two well-known companies to help you make a suitable decision. This article will explore Cri Genetics and 23andMe, compare their services, and discover the differences that set them apart.

Did You Know?

Your 23andMe DNA Data includes 700,000 markers, which can be used to learn everything from disease risk and drug sensitivities to nutritional requirements and fitness parameters. Learn more:

About 23andMe

23andMe offers multiple services, including ancestry reports, health and wellness reports, and genetic matching with relatives. 

It's one of the leading players in the genetic ancestry testing niche.

23andMe offers several tools to make the most of your ancestry test results.

One such tool is called DNA Relatives. 

This remarkable technology compares you with DNA matches with a common ancestor, revealing potential relatives you were unaware of.

At 23andMe, you can purchase an ancestry report for $99 or a health+ancestry report for $199. 

In addition to your health+ancestry service, if you want access to advanced reports and features throughout the year, you can opt for the premium membership for $268.

About Cri Genetics

Cri Genetics has rapidly gained attention for its cutting-edge approach to DNA testing. 

This company was founded by the experienced molecular geneticist Dr. Alexei Fedorov in 2016.

Cri Genetics aims to empower individuals by unlocking valuable insights hidden within their DNA.

Cri Genetics focuses on providing personalized genetic analysis to individuals interested in exploring their genetic makeup, health tendencies, and wellness potential. 

Moreover, Cri Genetics provides specialized reports that include Ancestry + Traits for $89 and Health + Ancestry for $109. Additional reports include Nutrition, priced at $99, and Allergy, priced at $199.

Please note that pricing may vary, and it is advisable to refer to the official sources for the most up-to-date information.

Cri Genetics vs. 23andMe: The Similarities

Cri Genetics vs. 23andMe: The Differences

Ancestry Services: Which One Is Better?

23andMe and CRI Genetics offer ancestry services but have different strengths and features.

23andMe

• It gives reports on over 47 distinct regions of your ancestry.
• FDA-authorized.
• It provides a more comprehensive health report than CRI Genetics, including information for certain genetic diseases, ancestry-based health risks, and wellness traits.
• It has a larger, over 5 million DNA database, which can make it more accurate for some people.
• It offers a variety of resources for building and exploring your family tree.

CRI Genetics

• It provides a "Famous People" section that shows people you may be related to.
• It includes an interactive map showing where your ancestors may have originated.
• It gives a timeline of when those ancestors entered your family tree.
• It offers an 8-week result guarantee or refund.
• Not FDA-authorized.
• DNA database size not revealed

It's important to thoroughly research and understand both companies' offerings before deciding. It is advisable to seek advice from healthcare experts, carefully evaluate the restrictions, and analyze the genetic testing outcomes.

Health Services: Which One Is Better?

Both 23andMe and Cri Genetics provide information on health services. However, it's important to note that these reports should never be considered a substitute for professional medical advice.

23andMe has extensive experience and FDA clearance, indicating that their health reports may cover a wider range of conditions in a more precise manner. In contrast, Cri Genetics may be lacking in this area.

Cri Genetics Reviews: What People Say

On most review platforms, Cri Genetics gets mixed reviews. Most of the negative reviews highlight concerns about the accuracy and details of the report.

• Facebook: 4.4/5
• Trustpilot: 4.1/5
• Amazon: 1.7/5

Despite good ratings on some of the platforms, many people have questioned the validity and accuracy of their results, which suggests a cause for concern.

Summary: Cri Genetics vs 23andMe - Which One Is Better?

The choice between Cri Genetics vs 23andMe ultimately depends on your needs and interests. If you're primarily interested in connecting with genetic relatives and exploring your overall ancestry composition, 23andMe's extensive customer database may be more beneficial.

On the other hand, if you're looking for a personalized genetic analysis, health reports, and wellness reports, Cri Genetics may be the better option.

Both companies have their strengths and have garnered positive reviews from customers. It's essential to research and understand what each company offers thoroughly.

Remember that genetic testing can provide fascinating insights, but it's essential to approach the results cautiously and consult a healthcare professional.

Whether you choose Cri Genetics or 23andMe, taking a DNA test can be an exciting journey of self-discovery.

Imagine waking up the day after a grueling workout, and your muscles feel like they've been hit by a truck. It's a familiar feeling for many fitness enthusiasts, but what does it mean? Is Delayed Onset Muscle Soreness (DOMS) a promising sign of muscle growth, or is it simply a side effect of your body recovering from the strain? Today, we dive deep into the science behind DOMS to unveil the truth about its role in your fitness journey.

Did You Know?

Some genes affect how your body responds to training, including inflammatory responses and muscle fatigue. People carrying certain gene changes may be more prone to DOMS or exercise-induced muscle damage than others. Learn more

What Is DOMS?

Delayed Onset Muscle Soreness or DOMS is muscle pain and stiffness that affects your body 12-24 hours after a workout.

These symptoms typically start to get better after 72 hours.

DOMS differs from pain during exercise, which might indicate injury.

It is most common in people who have just started or returned to exercise after a long gap.

DOMS can hinder your workout plans and fitness goals.

Symptoms Of DOMS

While local muscle pain is one of the main symptoms of DOMS, it can be much more than that:

• Swelling of affected limbs
• Stiffness of the joint accompanied by reduced movement.
• Tenderness to the touch
• Elevated creatine kinase (CK) enzyme in the blood, signaling possible tissue damage.
• In extreme cases, kidneys might be at risk due to muscle damage. 

What Causes DOMS

Exercising puts physical stress on your muscles.

It creates microscopic tears in your muscle fibers.

As your muscles heal from this abnormal stress, inflammation causes soreness.

DOMS is the most common after eccentric workouts.

They include jogging downhill or lowering a barbell. 

When you do these exercises, your muscles lengthen while contracting.

The severity of DOMS will depend on how hard you have worked out. 

How Does DOMS Pain Feel Like?

People often describe DOMS as a dull and aching sensation in the muscle group engaged in the workout. Some may also feel a "burning" sensation along with stiffness.

Is DOMS A Sign Of Muscle Growth?

DOMS occurs when you put your body through sudden heavy exercise.

It safeguards your body from further pain and severe damage.

However, it is not necessarily a sign of muscle growth.

DOMS stops occurring quite quickly after your body gets used to strenuous workouts.

It is important to note that you can still achieve muscle growth without suffering from DOMS.

Genetics Behind DOMS or (exercise-induced muscle damage)

Studies indicate that genetics might play a part in the occurrence and severity of DOMS.

Inflammatory Responses in DOMS

Women may experience less DOMS pain than men due to different inflammatory responses of the body.

Estrogen protects the body from muscle damage and inflammation.

One study showed that women on birth control had less muscle soreness after exercise than those without birth control.

Muscle Fiber Distribution and DOMS

The alpha-actinin-3 protein (ACTN3) gene is found in fast-twitch muscle fibers.

Fast twitch muscle fibers are essential for power and strength, as opposed to slow twitch muscle fibers needed for endurance.

ACTN3 gene reduces damage due to eccentric muscle contraction.

Humans have three types of ACTN3 genes: RR, XX, and RX.

People with the XX variant have a deficiency of the ACTN3 gene.

Deficiency of this gene might make a person more prone to suffer from DOMS.

The Myosin Light Chain Kinase (MLCK) gene may also play a part in muscle soreness.

Athletes were tested for this gene.

Those with a homozygous CC variant of this gene had less muscle soreness than those with a heterozygous CA variant. 

Risk Factors For DOMS

The most significant risk for DOMS is starting an intense workout suddenly without a warmup.

However, some studies show that DOMS affects men more than women.

A lower blood creatine kinase level can lead to lesser DOMS.

Women typically have less CK enzyme in their blood than men.

The presence of specific genes also increases the risk of DOMS.

Effective DOMS Recovery After Your Workout

Usually, the pain and discomfort of DOMS fade after 72 hours of onset.

However, if you want to ease the pain and discomfort, here are some tips that can help:

• Massage therapy: Massage can help reduce the pain and discomfort of DOMS.
  It releases muscle tension and increases blood flow in the affected area.
  It is best to get a massage after 48 hours of a hard workout.
  You can also invest in massage gadgets if you can't go to a professional.

• Cold baths: A cold bath 24-48 hours after your workout will help decrease swelling.
  Some athletes even swear by ice baths.
  However, you can also start with ice packs if ice baths are too intense.

• Warm baths: Warm baths can also help ease muscle pain.
  They have the added benefit of helping you relax and improve your sleep.

• Protein and carbs diet: Eating a protein and carbs-rich snack after a workout can help counter DOMS.
  Proteins help repair damaged muscles and ease soreness and inflammation.
  Carbs replenish glycogen, which is the body's stored energy.

• OTC pain relievers: You can apply a topical pain reliever a few times daily if you are sore in a particular place.
  Essential oils may also help ease discomfort.
  You can take OTC non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen if you have severe pain.
  However, it is always advisable to consult your doctor before starting any medicine.

Is It Okay To Train With DOMS?

While working out with DOMS can seem very exhausting, low-impact cardio, like brisk walking or swimming, can actually promote recovery.

Even stretching exercises like yoga can help alleviate t

How To Prevent DOMS?

While it might be impossible to avoid DOMS, it might be possible to reduce its intensity.

Here are some tips to avoid DOMS:

• Start slow: DOMS typically affects people who suddenly do an intense workout without prior planning or preparation.
  In other words, it affects beginners and those working out the most after a gap.
  Intense exercise often comes as a shock for people with little working out experience.
  So, starting slowly and getting your body used to exercise is advisable.
  Light training will still help you build strength if you are a beginner.
  Gradually increase the intensity of your training sessions without putting too much pressure on your body.
  Too hard and fast can make you extremely sore and crush your motivation. 

• Doing adequate warmups and cool down before and after working out: The most common cause of DOMS is sudden heavy exercise.
  Doing a low-intensity jog can help ease your body before a workout session.
  Similarly, stretching your body post-workout is a great way to keep DOMS at bay.

• Proper hydration: staying hydrated is vital to good recovery after training sessions.
  Studies show that dehydration can increase the severity of DOMS.
  Make sure that you drink water before and after working out. 

Summary: Is DOMS A Sign Of Muscle Growth?

Delayed Onset Muscle Soreness or DOMS often affects those who suddenly start working out.

Muscle pain and stiffness occur 12-24 hours after a workout.

Many people say that DOMS is a sign of muscle growth.

However, new studies show it might not be a sign of muscle growth.

Some genes are associated with an increased risk of DOMS.

Gender also plays a role when it comes to the severity of DOMS. 

Doing proper warmups before starting any exercise and using OTC and massage therapy might help counter symptoms of DOMS.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830646/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983298/

https://www.medicalnewstoday.com/articles/delayed-onset-muscle-soreness/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1250256/

Despite affecting 176 million people worldwide, very little is known about the cause of endometriosis. The path to diagnosis is notoriously lengthy, averaging five years, as symptoms are often dismissed as "normal" or something one must simply endure. This delay and misunderstanding underscore a critical gap in awareness and knowledge about endometriosis. Management and treatment of this condition involve understanding the root cause. Recent studies indicate that there may be a genetic component at play. This article explores what this means and further touches upon hereditary factors and tips to lower endometriosis risk.

About Xcode Life

What Is Endometriosis?

Endometriosis is when tissues lining the uterus start growing outside the uterus. 

The function of endometrial tissue is to line the uterus. 

This layer of tissue grows, thickens, and ultimately breaks down during every menstrual cycle. 

However, in endometriosis, this same tissue starts growing on ovaries and fallopian tubes and does not leave the body. 

This condition can cause pain and issues with fertility. 

Signs And Symptoms

Endometriosis can show a variety of symptoms:

• Chronic pelvic pain
• Bleeding between periods and sometimes from the rectum
• Frequent and heavy periods 
• Passing large blood clots during periods
• Pain during sex
• Fertility problems

Causes And Risk Factors

The specific cause of endometriosis is unknown.

However, genetic predisposition can make you prone to developing this disease.

Other risk factors include:

• Alcohol use
• Stress
• Exposure to pollution
• Exposure to hormone-disrupting chemicals
• Advanced age
• Surgical scar complication, where endometrial tissue may attach to a cut made in the abdomen during surgery, such as a C-section.

Is Endometriosis Genetic?

Studies report that those with a family history of endometriosis are more likely to have the condition themselves, suggesting a genetic component to this condition. 

However, more research is needed to identify the genes underlying this condition and establish any inheritance patterns.

The following sections explain what we know so far regarding the genetic nature of endometriosis.

Family Clustering Of Endometriosis

Studies have found that women who have a close female relative who has endometriosis are 5 to 7 times more likely to suffer from the condition themselves.

Endometriosis that occurs in families tends to be more severe than sporadic cases.

Genes Associated With Endometriosis

Scientists continue to look for specific genes that cause endometriosis.

In a study published in 2019, researchers identified more than two dozen genes that have been linked to endometriosis.

However, no specific gene that causes the disease was identified.

Instead, scientists have found that endometriosis is caused due to a complex interaction between genes.

Let’s explore some of the genes identified in this study and how they can potentially contribute to endometriosis:

Can You Inherit Endometriosis?

Endometriosis can run in families, meaning that you have an increased risk of having this condition if any of your close female relatives have it.

Endometriosis is inherited in a polygenic or multifactorial way.

This means that multiple genes are involved in influencing your likelihood of developing endometriosis. 

How Polygenic Inheritance Works

Scientists have found that endometriosis is inherited in a multifactorial way.

This means no one specific "endometriosis gene" determines if you will have endometriosis.

The effect of multiple genes together contributes to the risk - all these genes have certain changes called variations, each of which contributes a small percentage of risk.

However, when these small risks are cumulatively considered, it can result in a high risk for endometriosis.

This is called polygenic inheritance, which talks about inheriting multiple gene changes associated with the risk. 

If you inherit only 1-2, your risk may be low to moderate. However, if you inherit multiple, then your risk may be on the higher side. 

It is also important to understand that genes alone do not influence if you will have endometriosis.

Environmental factors, too, play a part in it, and the interaction of your genes with the environment ultimately determines if you will have the condition. 

Is Genetic Endometriosis Preventable?

There is no evidence to suggest that you can prevent endometriosis.

However, you can lower your chances of having the condition if it runs in your family.

Endometriosis depends on estrogen concentration in the body, and you can lower levels of this hormone using these strategies:

• Limiting caffeinated drinks to once a day
• Cutting down on alcohol
• Exercising regularly
• If you use birth control, switching to something that has no estrogen in it

Other ways to lower your risk include:

• Increasing omega-3 fat intake - helps reduce inflammation
• Cutting down on red meat - red meat may increase inflammation and estrogen levels

Endometriosis can cause fertility problems.

If you have endometriosis and are trying to get pregnant, consult a doctor.

You might need surgery to remove endometrial tissue. 

Will I Get Endometriosis If My Mom Had It?

Your chances of getting endometriosis increase seven times if your mother or any other first-degree female relative has it.

However, it doesn't doesn't mean that you are bound to have it.

Inheritance of endometriosis is a complex phenomenon and depends on several genetic and environmental factors.

Endometriosis may not always occur, even if it runs in your family.

Is There An Endometriosis Genetic Test?

Endometriosis is diagnosed using the patient's clinical symptoms and a pelvic ultrasound.

Immunological and genetic tests can be performed to confirm if a person has endometriosis.

However, they can't diagnose definitively since a single gene does not cause endometriosis.

Summary: Is Endometriosis Genetic?

Endometriosis is a condition that affects millions of women worldwide every year.

However, doctors and scientists are still not sure what causes it.

This leads to delayed diagnosis and women not getting adequate treatment.

But now, new studies show that endometriosis is genetic.

It has a complex inheritance pattern and runs in families.

However, due to its complex pattern of inheritance that depends on multiple genes, there's no specific genetic test to determine if someone will have endometriosis.

However, this key finding is that endometriosis will help women get treated for this condition faster and more effectively. 

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346178/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447774/

https://pubmed.ncbi.nlm.nih.gov/26947452/

https://www.medicalnewstoday.com/articles/is-endometriosis-hereditary

https://www.who.int/news-room/fact-sheets/detail/endometriosis

https://www.nhs.uk/conditions/endometriosis/