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The mantra "eat your greens" is a cornerstone of healthy living advice, highlighting the essential nutrients like vitamins, minerals, antioxidants, and fiber found in green vegetables and fruits. These components are crucial for maintaining a healthy lifestyle. However, in today's fast-moving world, there's a constant search for a nutritional shortcut that can deliver these benefits more conveniently. Enter liquid chlorophyll, which has emerged as a popular wellness trend. Touted by celebrities and influencers on social media for its wide array of health benefits, including boosting energy levels and its cancer-fighting properties, this drink has sparked interest and debate. But is it truly the miracle supplement many claim it to be? This article delves into whether liquid chlorophyll can stand up to the claims and examines if it's the modern equivalent of green juice.

What Is Liquid Chlorophyll?

Chlorophyll is the green, photosensitive pigment in plants that helps them prepare food. 

It contains vitamins, minerals, and antioxidants.

For this reason, it is said to be therapeutic for the body.

The best way to experience the health benefits of chlorophyll is by eating your greens.

However, there are several supplements containing chlorophyll available for consumption.

They contain chlorophyllin, a semi-synthetic form of chlorophyll, and are available in liquid, powder, and tablet forms.

The liquid version of chlorophyllin supplements is called liquid chlorophyll.

Chlorophyll supplements may be more effective because chlorophyll in plants may not survive digestion or be adequately absorbed.

Besides chlorophyllin, chlorophyll supplements also contain copper and magnesium.

7 Health Benefits Of Liquid Chlorophyll

Liquid chlorophyll is marketed as the next best thing among nutritional supplements due to its potential health benefits.

Here are some possible health benefits:

Anti-cancer Properties

Liquid chlorophyll is said to be a good source of antioxidants, which helps fight against oxidative damage. This has been linked to anti-cancer properties. However, no human studies have validated this.

Boosting Immune System

Studies suggest that chlorophyll may help improve white blood cell production, which is the cornerstone of our bodies' immune system.

Skin Healing

The synthetic form, chlorophyllin, has shown possible wound-healing effects by reducing inflammation and bacterial growth on the site of injury.

Natural deodorizer

The mechanism behind this property is unclear. By fixing the digestive system, it may reduce both bad breath and body odor. However, no studies support this claim.

Boosting Digestion

Liquid chlorophyll may have a positive effect on the gut bacteria and hence may boost the digestion process. Further, it can also increase the frequency of bowel movements, which may be particularly useful for those suffering from constipation.

Are The Health Benefits Scientifically Backed?

Despite the several claims about the health benefits of liquid chlorophyll, it is important to understand that there is minimal evidence to back them.

Research has been primarily done on its topical use, and some studies have shown that it may be useful in acne treatment

However, according to experts, more studies are required to make definitive recommendations.

Further, no amount of liquid chlorophyll can replace a healthy diet that includes adequate portions of leafy greens, fruits, whole grains, and healthy fats.

How To Take Chlorophyll?

Powder Vs. Liquid Form

Chlorophyll liquid supplements are better than other forms, like tablets and powder, as they are absorbed by the body more easily.

Though consuming it has no significant risks, some people may experience nausea or diarrhea.

Always consult with your doctor before taking liquid chlorophyll or chlorophyll supplements.

Chlorophyll Supplements

Chlorophyll supplements are available in liquid, tablet, and powder forms.

These supplements are available in a wide range of strength and formulations.

Chlorophyll supplements are usually safe and have the recommended dosage mentioned on their packaging.

If you experience any reaction or side effects from the chlorophyll supplements, discontinue them and consult your doctor immediately.

How Often Should You Take Liquid Chlorophyll?

There is no recommended dosage or frequency of taking liquid chlorophyll.

What To Avoid When Taking Chlorophyll?

If you are taking liquid chlorophyll, avoid taking the following medications:

Since there is limited research on the consumption of liquid chlorophyll, there isn’t a recommended dosage.

Dietary Guidelines for Americans 2020-2025 says adults should consume 2 to 3 cups of vegetables daily.

Always consult your doctor for the recommended dosage for you.

Liquid chlorophyll is available in bottles.

Depending on your chosen brand, the method of consumption may vary.

Some brands recommend you take the liquid directly from the bottle, while others may require you to mix the supplement with water or juice.

Is Liquid Chlorophyll Safe?

Liquid chlorophyll and other forms of chlorophyll supplements have been used for several decades.

No significant side effects have been reported so far.

Researchers have not found toxic effects of chlorophyll on humans but recommend moderate consumption.

Side Effects Or Risks Of Liquid Chlorophyll

A few side effects that may occur in some individuals include:

Who Should Not Take Liquid Chlorophyll?

Liquid chlorophyll may interact with some medications and nutritional supplements. 

Though there is no list of drug interactions with liquid chlorophyll, always inform your doctor about all the medicines you are taking.

This will help your doctor determine if liquid chlorophyll is safe for you.

Also, there is limited research on its effects on pregnant and breastfeeding women.

So, if you are pregnant or breastfeeding, check with your healthcare provider before consuming it.

Does Liquid Chlorophyll Expire?

Since liquid chlorophyll is semi-synthetic in nature, it does expire.

Always check the bottle and/or product packaging for the product's expiry date.

Alternatives To Liquid Chlorophyll

The best alternative to liquid chlorophyll is consuming green vegetables rich in the pigment.

A few vegetables that are rich in chlorophyll include:

Besides chlorophyll, these green vegetables are rich in fiber, vitamins, and minerals sources.

Summary

References

The 23andMe+ Total Health membership is a new service of the 23andMe genomics brand.

This one-of-a-kind membership will include all the features and reports of their 23andMe+ premium package, along with exome sequencing, biannual blood testing, and virtual clinical consultation options.

According to the brand, this package would focus on ongoing prevention and early detection of inherited health conditions.


You can log in to your 23andMe account & download your DNA data. Upload it to Xcode for insights into 700+ health and wellness traits at 55% OFF!


About The 23andMe+ Total Health Service

23andMe is a personal genomics company that offers direct-to-consumer genetic testing kits and services for consumers worldwide. 

Like other personal genomic brands, 23andMe collects saliva samples to generate ancestry, health predisposition, carrier status, wellness, traits, and pharmacogenetic reports. 

One of the popular services of this brand is the 23andMe+ Premium membership, which includes ancestry, health, and traits reports. 

This annual membership costs $298/year, with the membership renewed at $69/year from the second year onwards. 

The 23andMe+ Total Health package is a newer addition that includes all Premium service features and three additional services - exome sequencing, biannual blood testing, and virtual consultations with certified genetic-based clinicians.

Features Of 23andMe Total Health

According to 23andMe, this Total Health package will focus on personalized recommendations for prevention and early detection of more than 55 health conditions caused by variations in about 100 genes. 

The following are four significant features of 23andMe+ Total Health.

Exome Sequencing

Exome sequencing is a genetic testing technique that focuses on exomes. 

Exomes comprise about 1% of the human genome and are protein-coding regions of genes. 

Studies show that many of the known mutations occur in the exomes, making exome sequencing an effective method to identify the risk of certain genetically occurring diseases. 

23andMe’s exome sequencing looks for over 55 health conditions that could be caused by gene mutations.

Bi-annual Blood Testing

Members may request an in-person blood test up to twice a year.

Initiated by an in-house clinician, the test would include 55+ biomarkers, including a comprehensive metabolic panel, complete blood count panel, advanced lipid panel, and endocrine tests. 

The results of the blood test would be available on the 23andMe app.

Access To Clinical Geneticists

Members would have a dedicated clinician to help discuss genetic reports, blood test results, and preventive health measures.

Limited virtual consultations and unlimited message options are available. 

23andMe+ Premium Membership

The 23andMe+ Total Health package will include everything the 23andMe+ premium membership offers.

This includes 190+ genotyping reports, 50+ ancestry reports, enhanced ancestry finder features, 40+ health disposition reports, 45+ carrier status traits, 10+ wellness traits, six pharmacogenetics traits, and 30+ other traits. 

Apart from these, 23andMe has recently included two additional features for premium members - health tracks and personalized health action recommendations. 


Everyone's reading: Unable To Access 23andMe Raw Data? This Is What You Can Do.


Who Cannot Avail of 23andMe Total Health Service?

The following people may be unable to avail of the 23andMe+ Total Health service.

Also, for now, the 23andMe+ Total Health plan is only available for new and non-genotyped customers. 

Existing members may have to wait until spring 2024 to integrate this service into their membership.

How Much Does 23andMe Total Health Cost?

The 23andMe+ Total Health membership will cost $1,188/year.

Other FAQs About 23andMe Total Health

Who Is Eligible?

New and non-genotyped customers 18 years or older living in the United States (except in HI, NJ, NY, OK, RI, and US territories) can opt for 23andMe+ Total Health.

I Am An Existing Customer. Can I Add It To My Current Account?

If you are an existing customer, you may have to wait until Spring 2024 to add the services to your current account. 

How To Activate The Membership?

After the purchase, they will receive the home kit that will give further instructions to activate the membership. 

How To Cancel The Membership?

Customers can cancel their membership by logging into their account and navigating to the accounts settings page. 

Cancellations will be processed at the end of the next billing cycle.

Summary

  1. The 23andMe+ Total Health package is a new prevention-based health membership offered by 23andMe.
  2. This membership includes all features of the 23andMe premium package, along with exome sequencing, biannual blood testing, and access to genetic clinicians. 
  3. According to 23andMe, this membership focuses on prevention and early detection of more than 55 health conditions.
  4. At $1,188/year, the membership can now be availed only by new, non-genotyped customers who are 18 years older and living in the United States (except in HI, NJ, NY, OK, RI, and US territories).
  5. Existing members may need to wait until Spring 2024 to access the 23andMe+ Total Health package. 

References

https://pubmed.ncbi.nlm.nih.gov/19684571/

https://medlineplus.gov/genetics/understanding/testing/sequencing/

Beyond vitamin C serums and retinoid creams, we are now stepping into another realm of skincare: LED light therapies. If you are someone who keeps up with skincare trends, you’ll probably already know that LED masks have quickly become celeb faves. Among the different color light therapies, red and blue are the ones commonly used. So, how do these work? Let’s dive right into the red light vs blue light therapy battle and see which one may suit your needs. 

Basics Of LED Light Therapies

LED light therapy is a new-age technology used to treat various skin conditions.

LED light therapies come in different types, with red and blue light therapy being the most common.

How Does LED Light Therapy Work?

LED Light therapy uses low-level light in different wavelengths and colors.

Each color targets skin issues at different depths. 

For instance, blue light treats the uppermost layer of the skin, while red light travels deeper into the skin.

What Does LED Light Therapy Do?

LED light therapy is helpful in treating many health conditions, such as:

LED light therapy has been found to be helpful in the treatment of superficial basal cell carcinoma in some people.

Different Types Of LED Light Therapies

Depending upon the type of condition and the depth of penetration required to treat it, doctors choose an appropriate wavelength of light.

The wavelength of light corresponds to visible colors. 

Based on this, there are different types of LED light therapies:

Red and blue LED light therapy are the most commonly used. 

Collagen is responsible for younger-looking skin that reduces with age.

During treatment, most specialists use a combination of LED light therapies.

Red Light Therapy

An illustration of a woman holding a LED right light mask. Around this are depicted the benefits of red light therapy.

Red light therapy is a type of phototherapy that uses the red light spectrum.

What Is It

Red light therapy promotes cell response in the body and increases cellular turnover.

It also boosts collagen production.

Red light is said to penetrate the mitochondria in the cells, increasing their function.

As a result, cell energy increases, bringing about cell rejuvenation and damage repair.

Red light therapy stimulates the body’s natural healing process, making skin cells healthier.

What Does It Treat?

Red light therapy has been used in dermatology for years to treat many skin conditions.

It is effective in treating 

Red light therapy also promotes wound healing.

Since red light therapy promotes collagen production, it may help reduce fine lines, wrinkles, and other signs of aging (dark spots, hyperpigmentation, etc.)

Blue Light Therapy

Blue light therapy uses the purple-blue light from the spectrum to treat skin conditions.

What Is It

Blue light LED is used to treat superficial skin conditions as it does not penetrate the deeper layers.

It is usually combined with other skin treatments like microdermabrasion and chemical peels for increased effectiveness.

Blue light therapy is sought after as it can kill acne-causing bacteria P. acnes, which live on the skin's surface.

What Does It Treat?

Blue light therapy helps treat

Red Light vs. Blue Light Therapy

(tabulate the differences on what it treats, how it works, benefits, cons, costs, etc.

Red Light TherapyBlue Light Therapy
DepthLonger wavelength of light, therefore, reaches deeper layers of the skin
Between 630 to 670 nanometers (nm)
Shortest wavelength, therefore, treats superficial skin conditions
Between 400-495 nanometers (nm)
What does it treat?Improves skin tone and texture
Reduces skin irritation and redness
Fades scars
Minimizes pores
Treats and prevents acne
Reduces inflammation
Treats and minimizes skin discoloration
Minimizes pores
How it worksBoosts blood flow
Stimulates collagen production
Increases cell energy, stimulating cell rejuvenation
Reduces inflammation in the keratinocytes (common in the outer layers of the skin)
Kills acne-causing P.acnes
BenefitsBest to rejuvenate aging skin
Has a wide range of applications
Best for treatment and prevention of acne
DrawbacksSome people may develop burns, blisters, or lesions if the red light therapy device is used for longer than 30 minutes or if the device is damaged.It is currently being studied to reduce acne breakouts.
Overexposure may contribute to accelerated skin aging, uneven pigmentation, and melasma.
Cost$25-$175 per session
At-home device cost: $300-$3,000
$400-$1,000

Which Is Better? Red Light Therapy vs. Blue Light Therapy

Ted and blue light therapies have their benefits and drawbacks.

Both these therapies have similar efficacies in treating mild-to-moderate acne vulgaris.

Red light therapy has advantages, with fewer adverse reactions compared to blue light.

Which is better? Well, combining red and blue light therapies can produce the best results.

Can I Use Both Red And Blue Light Therapy?

Most dermatologists will use a combination of red and blue light therapy.

While blue light can take care of the conditions on the outermost layer of the skin, red light penetrates deeper into the skin to reduce oil or sebum production.

So, combining both red and blue light therapies is more effective in treating skin conditions.

Is There Any Downside To Red Or Blue Light Therapy?

Red and blue light therapies are safe and relatively risk-free. However, some people may experience a few side effects, such as

Summary: Red Light Therapy vs. Blue Light Therapy

References

Now and then, social media comes up with hacks and tricks claimed to be "life-changing." Usually, there is no credible research to back up such wild claims. Worse, sometimes, these hacks end up harming people more than doing anything beneficial. A recent hack is a mocktail that claims to help you sleep better, made famous on TikTok. Called the Sleepy Girl Mocktail, it has garnered millions of views on this platform, and users claim this magic potion helps you sleep better. While the ingredients seem promising, experts are skeptical. So, what is the truth? Does the Sleepy Girl Mocktail really help you sleep better?


Genetics is one of the biggest influencers of sleep. Certain genes affect the sleep cycle, time taken to fall asleep, tendency to nap risk of snoring or apnea, sleep duration, deep sleep, and much more. It is now possible to understand the genetic intricacies of sleep and improve your sleep health for good using your existing ancestry genetic test DNA data.
Learn more.


What Is The Sleepy Girl Mocktail?

The Sleepy Girl Mocktail is the newest sleep aid that is doing the rounds on TikTok.

It's a drink made from magnesium powder, tart cherry juice, and soda that users say lets them sleep better.

The recipe was first posted on TikTok by Gracie Norton in 2023.

Since then, it has gained 58 million views on that platform.

The Ingredients Explained

The two main ingredients in the Sleepy Girl Mocktail, tart cherry juice and magnesium powder, have been shown to promote sleep.

How Does The Sleepy Girl Mocktail Help You Sleep Better?

The Sleepy Girl Mocktail might be beneficial for sleep.

Both magnesium and tart cherry juice, the main ingredients of the Sleepy Girl Mocktail, have some benefits for good sleep.

However, more evidence is required to support the claim.



What Does Science Say?

The ingredients in the Sleepy Girl Mocktail may help you sleep better.

The magnesium in this mocktail might help counter deficiencies and increase the production of GABA, a neurotransmitter that helps keep anxiety and stress at bay.

The melatonin in tart cherry juice can help induce sleep.

However, experts are not sold on the idea of this mocktail being an effective sleep aid.

In fact, some amount of the placebo effect may play into this.

If you regularly make this mocktail and consume it before bedtime, your brain may be tricked into making an association between both.

So whenever you make this mocktail, your brain starts sending signals to the, you signal to your body that it's time to fall asleep.

It becomes a part of your bedtime routine that relaxes and helps you unwind.

This eventually leads to sound sleep rather than the drink itself.

The “Sleepy Girl Mocktail” Recipe

Here's the recipe for the "Sleepy Girl Mocktail.":

An illustration of the Sleepy Girl Mocktail in a glass with its ingredient listed on the side.

Do Doctors Recommend The Sleepy Girl Mocktail?

Despite its apparent health benefits, doctors and experts don't recommend relying solely on the Sleepy Girl Mocktail for sleep.

This is because numerous factors like diet, physical activity, stress levels, hydration, etc. can affect sleep.

While the magnesium and tart cherry juice might help some of these, not all can be solved with this mocktail.

Further, there is little only scientific evidence to back the claims being made on social media about this miracle concoction.

Pairing it with other good sleep habits, such as staying away from devices just before sleep or creating a calm environment in the bedroom, can help you sleep better.

Are There Any Side Effects?

Although the effectiveness of the Sleepy Girl Mocktail is questionable, the concoction is unlikely to cause any harm.

However, that does not mean you can consume large quantities of it without any side effects.

Is Sleepy Girl Mocktail Safe To Use Everyday?

There are no serious health risks associated with the Sleepy Girl Mocktail.

So it can be safe to use everyday.

However, if you have a health condition that makes consuming either magnesium or tart cherry juice risky, we advise consulting your doctor first. 

When Should You Drink Sleepy Girl Mocktail?

It's a good idea to drink the Sleepy Girl Mocktail 2 hours before going to bed.

Remember to pair it with a bedtime routine to increase its effectiveness.

Healthier Habits For Better Sleep

Besides the Sleepy Girl Mocktail, here are a few healthy habits to follow if you are trying to get better sleep:

Summary

The Sleepy Girl Mocktail is a concoction of tart cherry juice and magnesium powder that helps you sleep better.

Magnesium is a muscle relaxant and might help promote sleep.

Tart cherry juice contains small amounts of melatonin, a hormone that regulates the body's sleep cycle.

However, experts have differing views that this mocktail alone might solve your sleep problems.

They recommend pairing it with other good sleep habits.

If you have a medical condition that restricts you from consuming either magnesium or tart cherry juice, make sure to consult your doctor before drinking this mocktail.

References

https://health.clevelandclinic.org/sleepy-girl-mocktail

https://pubmed.ncbi.nlm.nih.gov/28901958/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/

An astonishing 90% of adults in the United States have experienced at least one cavity in their lifetime. While factors such as oral hygiene practices and consumption of sugary beverages are commonly blamed, the roots of dental issues often delve much deeper. Research indicates that a variety of dental conditions, including cavities, tooth decay, and misaligned teeth, may have familial ties. This suggests that inheriting "bad teeth genes" from your parents could significantly elevate your susceptibility to a range of dental problems.

How Does Genetics Impact Your Dental Health?

Humans inherit 50% of their DNA from their biological mothers and the other 50% from their biological fathers.

That’s why we all share features with our biological parents - blue eyes, curly hair, food preferences, etc. 

In the same way, we also may share disease risk - how likely we are to develop heart disease or diabetes - though it’s not as straightforward.

Even dental issues fall into this pattern.

Here are some oral health attributes that may be inherited:

Bad Teeth Genes: What Dental Issues Can Be Inherited?

Crooked Teeth

Crooked teeth or misaligned teeth are conditions that affect many children and adults.

In severe cases, it can cause problems with speech.

It is usually corrected using braces.

You can have crooked teeth due to genetic and environmental factors.

Teeth alignment depends on the number and size of teeth, size of jaw, and occlusion (how the teeth come together when we chew).

Your genes determine all these factors.

 However, some other factors, like sucking your thumb and thrusting your tongue towards your teeth, also result in crooked teeth.

Interestingly, these behaviors, too, have genetic predispositions.

So, if you have crooked teeth, chances are that it runs in your family.

Periodontal Disease 

Periodontitis or gum inflammation is one of the most common types of periodontal disease.

There are two types of periodontitis: chronic periodontitis (CP) and aggressive periodontitis (AgP).

Studies have found that AgP is more likely to be genetic than CP.

Another study has shown that a gene named FAM5C is most likely to contribute to AgP, especially in older adults.

Cavities

Cavities are usually caused by poor oral hygiene, smoking, and eating sugary and starchy foods.

However, you might become more susceptible to cavities if it runs in your family.

Less saliva production is a genetic risk factor for developing cavities.

A thin or weak enamel might also make you prone to developing cavities.

Tooth Decay

Tooth decay is caused by the formation of dental plaque, a sticky, bacteria-filled film that forms on the tooth.

This plaque changes into a hard substance called dental calculus when you don't brush your teeth.

Sugary foods are the most common cause of tooth decay.

However, genes might make you more susceptible to tooth decay.

You might be prone to tooth decay if you have underdeveloped or weak enamel. 

A lowered immune response will also give free rein to the oral bacteria, which might lead to tooth decay.

Yellow Teeth

Tooth color is determined by several factors, some of which are intrinsic while others are extrinsic.

Enamel, the outermost layer of teeth, is opaque white, while the underlying dentin is yellow.

People who are born with thin enamel have teeth that look yellow.

But this can also happen due to age when the enamel wears off, exposing the underlying yellow dentin.

Tooth color is determined by how your teeth develop in your fetal life.

If exposed to the antibiotic tetracycline in the womb, you will likely have yellow teeth.

Teeth can also become stained due to smoking or drinking coffee.

All these reasons show that you can have yellow teeth due to genetic and environmental factors. 

Oral Cancer

The most prevalent risk factor for oral cancer is tobacco use.

However, this cancer might run in families.

Squamous cell carcinoma (SCC) is the most common type of oral cancer.

You are more likely to develop SCC in your mouth or head region if your close relatives, such as a parent or a sibling, have this condition.

What Are The Bad Teeth Genes To Watch Out For?

If you have more or less than the normal number of teeth in your mouth, it might lead to misalignment and crowding.

The genes that usually cause this anomaly are MSX1, PAX9, EDA, and AXIN2.


Hand-picked Content For You: How Does Calcium Deficiency Affect Teeth?


Signs and Symptoms Of Bad Teeth Genes

How Can You Overcome The Effects Of Bad Teeth Genes?

You can't control your genes and their effect on your oral health.

However, you can always be more vigilant about your oral hygiene routine to overcome the effects of bad teeth genes.

Summary

Dental issues can be a result of both genetic as well as environmental factors.

You might be born with bad teeth genes, but it does not mean caring for your teeth is pointless.

Common dental problems like tooth decay, cavities, and gum inflammation are all influenced by genetic risk factors.

However, sugary foods and smoking can also increase the risk of developing these conditions.

So, being vigilant about your oral health is always a good idea. 

If you have bad teeth genes and dental problems run in your family, consult your dentist.

You might need some extra products or care to maintain your oral health.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192175/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449725/

https://www.news-medical.net/health/Are-Genes-Involved-in-Tooth-Decay-and-Gum-Disease.aspx

https://www.nature.com/articles/s41421-019-0126-6

https://pubmed.ncbi.nlm.nih.gov/23318742/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010053#s2

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Do you have your 23andMe DNA data?

Learn about your MTHFR gene status for free!


WATCH: How to interpret your MTHFR report


What is MTHFR?

MTHFR stands for methylenetetrahydrofolate reductase and is produced by the MTHFR gene.

MTHFR enzyme performs the function of adding chemical (methyl) groups to folic acid (Vitamin B9) in order for the body to utilize it efficiently.

This process is also necessary for the process that converts the amino acid homocysteine to another amino acid, methionine.

Detailed schematic representation of homocysteine to methionine conversion
Detailed schematic representation of homocysteine to methionine conversion

With your 23andMe raw data, you can learn a lot about your MTHFR gene through the Methylation test.

But, why should you learn about your MTHFR gene status?

All of us have two copies of the MTHFR gene, one from each biological parent. However, the type of MTHFR gene differs from person to person.

To explain this better, let’s take the example of blood groups. All of us have red blood. But you may have an O+ve blood type, while the other person may be A-ve - and these different blood groups have different health implications. 

Like how O+ve and A+ve are the most common blood types, the MTHFR gene also has 2 common variants (type): C677T and A1298C, the former being more common than the latter. These are called the MTHFR gene mutation.

About 40% of the American population have the C677T type, which has been associated with up to 80% reduction in the enzyme’s efficiency

Health Implications of MTHFR Gene Mutations

MTHFR mutation inheritance

When the MTHFR enzyme levels are reduced, it can lead to various health complications due to homocysteine (harmful amino acid) buildup.

They include:

Once you learn about the type of MTHFR gene you carry, the effects of it can be made better by simple fixes such as dietary changes and folic acid supplements. 

What is an MTHFR test? 

An MTHFR gene test examines variations in the MTHFR gene. 

This test does not need a medical prescription.  It can be performed in a major genetic diagnostic lab such as Quest or LabCorp. 

The aforementioned mutations (along with other smaller ones) are tested for in the MTHFR gene to provide the MTHFR gene status

More readily, the 23andMe MTHFR status can be learned from your 23andMe raw data. Anyone with 23andMe raw data can upload their DNA raw data to xcode.life to learn about their 23andMe MTHFR status. 

So, the MTHFR “test” does not necessarily have to be a test but can be as simple as uploading your 23andMe raw data (if you already have it) and downloading your results.

Which Companies Test For MTHFR Mutations?

There are many service providers and online tools that help you find out about your 23andMe MTHFR status. Some of them are listed below:

  1. Xcode Life: Almost 40 SNPs related to methylation and MTHFR are reported as part of the Xcode life MTHFR and Methylation report. You can upload raw data from most major ancestry companies such as 23andme, Ancestry DNA, Family Tree DNA  (FTDNA), and others (view the complete list here) and learn about your 23andme MTHFR status. The reports come with a detailed set of recommendations that guide you through the dietary changes necessary to mitigate the enzyme deficiency.
  2. Genetic Genie is a tool that accepts raw data only from 23andMe
  3. Genetic life hacks blog: It is not a tool but has a lot of information dedicated to methylation and the MTHFR gene that you can use as a reference if you have your raw data and a little knowledge about how SNPs work. However, if you do not have such a background, do not attempt to interpret the information all by yourself.

Steps To Test For MTHFR Gene Mutation

  1. Download your DNA raw data file from your ancestry test service provider:
    23andMe DNA Data Download Guide
    AncestryDNA DNA Data Download Guide
    Family Tree DNA Data Download Guide
  2. Once you can access your data, head over to www.xcode.life and purchase the MTHFR and Methylation report. You can also buy the Wellness Pack, which includes 5 other reports and has a $50 OFF!
  3. Fill out the required details and complete your transaction.
  4. Once this is done, you'll be taken to your account dashboard, where you can upload the downloaded data.
  5. Within 12-24 hours of the upload, you'll receive the report(s) directly to your email inbox!

How to check my MTHFR and Methylation Test Report for MTHFR Status

The first section of your report will include the 2 main mutations of the MTHFR gene.

This section, "PROMINENT MTHFR SNPS," includes the 2 SNPs:

  1. rs1801133 - C677T
  2. rs1801133 - A1298C

The bar graph below will indicate the combined result for these SNPs, which is "MODERATELY REDCUED MTHFR ENZYME ACTIVITY," in this case. This indicates a genetic likelihood of moderately functioning MTHFR enzyme.

Snippet of MTHFR and methylation test report with 23andme DNA data

Under the "OTHER MTHFR SNPS," we profile other variants that have a mild effect on the MTHFR enzyme activity but are not considered significant individually.

In the example below, for some, the individual carries one or two copies of the risk and all, and for others, they have two copies of the normal allele. This may have a mild effect on the MTHFR enzyme functioning.

Snippet of MTHFR and methylation test report with 23andme DNA data

With simple dietary modifications or folic acid supplements, you will be able to mitigate the enzyme deficiency.

Food recommendations for MTHFR enzyme deficiency

If you already have your DNA raw data from an ancestry test you may have done, you can easily find out your 23andMe MTHFR status from your DNA raw data with the Methylation report. Otherwise, you may consider an ancestry test for $99 or less, so that you can get your genetic raw data for further analysis. Once you have your raw data, you can upload it to xcode.life for your 23andMe MTHFR Methylation status report.

References

  1. https://www.ncbi.nlm.nih.gov/books/NBK6561/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326479/
  3. https://pubmed.ncbi.nlm.nih.gov/17433898/
  4. https://en.wikipedia.org/wiki/Race_and_genetics#Genetic_variation
  5. https://en.wikipedia.org/wiki/Nucleotide
  6. https://www.healthline.com/health/homocysteine-levels

More About MTHFR Gene Mutations

Updated May 2023

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