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PCOS: An Overview

PCOS (polycystic ovary syndrome) is a prevalent condition affecting women of reproductive age.

It usually starts in adolescence, with symptoms that can change over time.

Key characteristics Of PCOS 

Although PCOS is a chronic condition with no known cure, various treatments can help manage and alleviate its symptoms. 

Lifestyle changes like regular exercise and a healthy diet can be helpful.

The exact cause of PCOS remains unknown, but a family history of PCOS or type 2 diabetes can increase a woman's risk, suggesting a potential genetic or metabolic link.

Is Spearmint Tea Effective For PCOS?

Spearmint tea demonstrates potential efficacy in managing PCOS symptoms, possibly due to its anti-androgenic properties. 

These properties could help reduce elevated levels of androgens commonly associated with the condition.

What Does Research Say?

Research indicates that spearmint has promising effects on managing PCOS symptoms. Here's what various studies have shown:

Animal Studies

In a 2010 study, the effects of spearmint oil on PCOS were evaluated in rats. 

The rats were divided into eight groups:

Rats in groups II, III, IV, and V were induced with PCOS using letrozole.

The results showed that spearmint oil reduced body weight, testosterone levels, ovarian cysts, and atretic follicles in PCOS rats. 

Additionally, it increased the number of Graafian follicles, indicating a restoration of ovarian follicles.

Another recent study in 2020 assessed the impact of a combination of spearmint and flaxseed extracts on PCOS-induced rats. 

24 rats were randomly divided into four groups:

  1. Control: Received distilled water
  2. Treatment-control (TC): Received the herbal extract combination without PCOS induction
  3. PCOS: Induced with PCOS and received distilled water
  4. Treatment: Induced with PCOS and received the spearmint and flaxseed combination

Results

The treatment group witnessed:

Human Studies

A 2010 study in Turkey investigated the anti-androgenic properties of spearmint tea in women with PCOS and hirsutism

42 volunteers were randomized to drink spearmint tea or a placebo twice daily for a duration of 30 days. 

Study Design and Methodology

Study Results

The preliminary findings are encouraging, suggesting spearmint tea could be a helpful and natural treatment for hirsutism in PCOS.

How Long Does It Take For Spearmint Tea To Balance Hormones?

The time it takes for spearmint tea to balance hormones can vary.

Some studies have shown that drinking spearmint tea twice daily for a month can lower testosterone levels in individuals with PCOS. 

At the same time, LH and FSH levels increased compared to those who consumed a placebo.

Other research indicates that improvements can be seen as soon as five days. The effectiveness often depends on initial hormone levels.

Those with slightly elevated testosterone might see quicker results, while significantly higher levels may require additional treatments.



Other Benefits Of Spearmint Tea

Spearmint tea offers various health benefits beyond its minty flavor. Here are some key advantages:

How Many Cups Of Spearmint Tea A Day Is Effective For PCOS?

Research shows that drinking 2-3 cups of spearmint tea daily can alleviate some symptoms of PCOS. 

It is particularly effective in reducing elevated androgen levels and the severity of hirsutism (excessive hair growth). 

While it holds promise for balancing hormones, individual responses may vary.

Side Effects Of Spearmint Tea

While spearmint tea is popular for its refreshing flavor and certain health advantages, excessive use can have several side effects. These include:


Others Are Reading: Top Five Teas For Better Gut Health In 2024


Spearmint Tea Consumption Guide For PCOS

Here are some easy ways to enjoy spearmint tea for PCOS:

infographic describing the various ways of consuming spearmint tea for PCOS

Is It Okay To Have Spearmint Tea Everyday?

Daily consumption of spearmint tea is generally safe for most people, with minimal risks reported by experts.

However, those who are pregnant, breastfeeding, or have certain health conditions should consult their healthcare professionals. This is important to ensure spearmint tea won't adversely affect their condition.

As always, moderation is key; starting with small amounts is wise if in doubt.

Does Spearmint Tea Affect Fertility?

Spearmint tea could potentially benefit fertility by aiding in the balance of FSH and LH levels.

In a study where women drank 2 cups daily for 5 days, there was a notable increase in LH, FSH, and estradiol.

Nevertheless, the current evidence is limited, and more research is required to fully assess spearmint tea’s effectiveness in improving fertility, especially among those with PCOS.

Can I Drink Spearmint Tea On An Empty Stomach?

Spearmint tea has been consumed on an empty stomach for centuries, particularly for its potential digestive benefits.

Traditional practices often involve drinking herbal teas, including spearmint, first thing in the morning to stimulate digestive processes. Many people also enjoy the refreshing taste it leaves in the mouth.

Summary

Spearmint tea shows the potential to lower androgen levels and ease PCOS symptoms like hirsutism due to its anti-androgenic effects.

Both animal and human studies suggest spearmint tea can lower testosterone levels and improve hormonal balance, but more research is needed for definitive conclusions.

Drinking 2 cups of spearmint tea daily may be effective in managing PCOS symptoms, but individual responses can vary.

Spearmint tea also offers other health benefits, including hydration, antioxidant support, improved digestion, and potential memory enhancement.

It is generally safe for most people, but those who are pregnant, breastfeeding, or have specific health conditions should consult with a doctor before regular consumption.

Spearmint tea should be considered as part of a broader lifestyle and treatment plan for PCOS rather than a standalone solution.

References

https://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788221

https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-020-00633-8

https://pubmed.ncbi.nlm.nih.gov/19585478

https://pubmed.ncbi.nlm.nih.gov/17310494

https://www.webmd.com/diet/spearmint-tea-health-benefits

https://medlineplus.gov/druginfo/natural/845.html

https://health.clevelandclinic.org/spearmint-tea-benefits

https://onlinelibrary.wiley.com/doi/10.1002/ptr.2074

An Overview Of Methylation

Methylation, simply put, is the addition of methyl (CH3) group to a molecule - it can be an enzyme, a hormone, or the DNA itself.

The methylation cycle encompasses a bunch of biochemical reactions that transfer methyl groups from one molecule to another - essentially like a game of passing the parcel.

Methylation is important for several functions in the body, including:

Methionine And Homocysteine

An important reaction in the methylation cycle is the conversion of an amino acid called homocysteine to another amino acid called methionine.

The buildup of homocysteine in the body has been associated with several health conditions like:



Important Steps In The Conversion Of Homocysteine To Methionine

  1. The MTHFR enzyme converts inactive vitamin B9 (folate) to active folate called 5-MTHF.
  2. 5-MTHF then donates a methyl group to homocysteine to convert it to methionine. This reaction is mediated by the methionine synthase enzyme and vitamin B12.
  3. The cycle gets completed with methionine getting converted back into homocysteine, releasing SAMe, a very important methyl donor, in the process.

Genes Covered In Xcode’s MTHFR And Methylation Genetic Test Panel

GeneDescription
MTHFRThe MTHFR gene produces the methylenetetrahydrofolate reductase enzyme. It converts folate into its active form. This is crucial for converting the harmful amino acid homocysteine to methionine, which is safe for the body. Two common variants in this gene are C677T and A1298C, which can lead to MTHFR enzyme activity and increased homocysteine levels.
MTRRThe MTRR gene produces the methionine synthase reductase enzyme. It plays a role in activating another enzyme, methionine synthase (MTR). The MTR enzyme directly converts homocysteine to methionine. Variants in the MTRR gene can result in impaired reactivation of MTR, leading to a buildup of homocysteine and reduced methionine levels.
MTRThe MTR gene produces the methionine synthase enzyme. This enzyme is responsible for the final step in the conversion of the amino acid homocysteine to methionine. Variants in the MTR gene can result in a buildup of homocysteine in the blood and decreased availability of methionine and SAM, which can disrupt DNA methylation and gene expression.
MTHFD1The MTHFD1 gene produces the methylenetetrahydrofolate dehydrogenase 1 enzyme that catalyzes the 3-step folate metabolism pathway. This is an important step in generating methyl donors for the methylation cycle. Variants in this gene can alter the levels or activity of the enzyme produced, and can lead to disturbances in the methylation cycle.
CBSThe CBS gene produces the cystathionine beta-synthase enzyme. It is crucial in the transsulfuration pathway, a branch of the methylation cycle. The CBS enzyme catalyzes the first step of converting homocysteine into another amino acid called cysteine. Variants in the CBS gene can impair this conversion, leading to increased homocysteine levels.
AHCYThe CPS1 gene produces the carbomyl phosphate synthetase enzyme. It plays an important role in the urea cycle which converts excess ammonia in the body to urea. This cycle regulates neuronal health and oxidative stress. Variants in the CPS1 gene have been associated with higher homocysteine levels. However, the mechanism behind this is unclear.
CPS1The CPS1 gene produces the carbomyl phosphate synthetase enzyme. It plays an important role in the urea cycle which converts excess ammonia in the body to urea. This cycle regulates the neuronal health and oxidative stress. Variants in the CPS1 gene have been associated with higher homocysteine levels. However, the mechanism behind this is unclear.
BHMTThe BHMT gene produces the betaine-homocysteine S-methyltransferase enzyme. It transfers a methyl group from a compound called betaine to homocysteine to convert it into methionine. Methionine is then converted into SAMe. Variants in the BHMT gene can affect the enzyme levels or activity and may result in higher levels of homocysteine.
NOS3The NOS3 gene produces the endothelial nitric oxide synthase (eNOS) enzyme. It is responsible for the production of nitric oxide in the endothelial cells. Variations in the NOS3 gene have been associated with higher homocysteine levels. The hypothesis is that nitric oxide modulates homocysteine levels through an effect on folate catabolism.
SHMTThe MAT1A gene produces the methionine adenosyltransferase enzyme. The two forms of the enzyme, MATI and MATII, help break down methionine into S-adenosylmethionine, a main methyl donor. Variants in the MAT1A gene influence homocysteine levels. Some studies report increased levels in resposne to dietary fat intake in those who have a MAT1A variant.
CTHThe CTH gene produces the cystathionine-gamma-lyase enzyme. It catalyzes the conversion of cystathionine to cysteine in the last step of the transsulfuration pathway. Variations in the CTH gene can lead to plasma elevation of total homocysteine levels. This can lead to a condition called cystathioninuria, an inborn error of metabolism.
MAT1AThe MAT1A gene produces the methionine adenosyltransferase enzyme. The two forms of the enzyme, MATI and MATII, help break down methionine into S-adenosylmethionine, a main methyl donor. Variants in the MAT1A gene influences homocysteine levels. Some studies report increased levels in resposne to dietary fat intake in those who have a MAT1A variant.
GNMTThe GNMT gene produces the glycine N-methyltransferase enzyme. It transfers a methyl group from SAM to glycine to generate S-adenosylhomocysteine (SAH) and sarcosine. Variations in the GNMT gene can result in lower levels of the enzyme, which may cause homocysteine levels to build up. However, this effect can be countered with folate intake.
MAOAThe MAO-A gene produces the monoamine oxidase A enzyme. It is an integral enzyme in the regulation of brain chemicals like dopamine, norepinephrine, and serotonin. For MAO-A to function well, it needs to undergo optimal methylation. Undermethylation of MAO-A can result in dysregulation of brain chemicals and has been associated with panic disorder.
COMTThe COMT gene produces the catechol-o-methyltransferase enzyme. This enzyme transfers a methyl group from SAMe (a by-product of homocysteine to methionine conversion) to brain chemicals like dopamine and norepinephrine. Variants in the COMT gene may lead to imbalances in the brain chemicals, increasing the risk of certain psychiatric disorders.

How To Interpret Your Xcode MTHFR And Methylation Genetic Test?

Here, we will break down the key sections of your report and provide answers to common questions.

Overview of the Report

The MTHFR report includes:

Understanding Your Results

Prominent MTHFR SNPs

The report focuses on the following SNPs within the MTHFR gene:

Depending on the genotype for these SNPs, your overall results are calculated. If the bar graph points to green, you likely have normal MTHFR enzyme levels.

If it’s in orange, you may need to up your dietary vitamin B9 intake.

If it’s in red, you may require a methylfolate supplement (which should be taken only after consulting your doctor).

Other Important Methylation Genes

Other than MTHFR, several important genes regulate the methylation process in the body. This section provides information on their activity.

The colored circles around the genes denote how well they function. 

Red and orange indicate the presence of risk alleles that interfere with the gene functioning and are associated with lower levels or activity of the enzyme produced by that particular gene.

Green denotes a normal functioning gene and hence is associated with normal enzyme levels/activity.

SNPs Analyzed

“SNPs ANALYZED" provides a comprehensive overview of the specific Single Nucleotide Polymorphisms(SNPs) present in the important methylation genes, which could affect the level/activity of the enzymes produced.

Sometimes, one copy of the variant allele may be shaded in green; this is because, in some SNPs, only two copies of the variant allele will likely have a negative effect. Single copy is still considered normal.

The * symbol indicates that the original SNP we analyzed was not found in your data, so a proxy SNP was used. Proxy SNPs are variants present very close to the original SNP and, hence likely will have the same effect on the gene activity.


Sean Spence Says,


What Supplements Should I Take Based On The MTHFR Report?

Based on your genetic variants, the following supplements may be beneficial:

Disclaimer

Before starting any new supplement regimen, it is crucial to consult with a healthcare provider. These recommendations are based on genetic predispositions and should be tailored to your individual health needs and circumstances. Your healthcare provider can help determine the appropriate dosages and monitor for any potential interactions with medications or other supplements you may be taking.

Other Frequently Asked Questions

How Often Should I Review My Genetic Information?  

It is good practice to review your genetic information annually or when you experience significant health changes.

Can I Share My Results With My Healthcare Provider?

Absolutely. Sharing your report with your healthcare provider can help tailor medical advice and interventions to your genetic profile. In fact, we recommend taking the help of your doctor to interpret all our reports.

How Accurate Are These Results? 

Genetic testing is highly accurate, but it is one piece of your overall health picture. It is essential to consider these results alongside other medical evaluations.

Conclusion: MTHFR And Methylation Genetic Test

Your MTHFR report is a powerful tool for understanding your genetic predispositions and taking proactive steps toward better health. Use this guide to navigate your results and make informed decisions about your lifestyle and healthcare. If you have further questions or need assistance, don't hesitate to reach out to a healthcare professional.

Prebiotics vs. Probiotics vs. Postbiotics

What Are Postbiotics?

The International Scientific Association of Probiotics and Prebiotics (ISAPP) formally defined the concept of postbiotics in 2021.

According to the ISAPP, the term postbiotics refers to 'preparations of inanimate microorganisms and/or their components that confer health benefits on the host.'

Beneficial gut bacteria produce short-chain fatty acids, B vitamins, enzymes, and amino acids.

These substances are postbiotics and are important to overall health and wellness.

For instance, amino acids are the building blocks of protein, and vitamin B supports your brain health and immune function.

Thus, postbiotics are byproducts of probiotics that support your health. 

What Are Some Common Postbiotics?

Here are some examples of postbiotics: 

Are Postbiotics Better Than Probiotics?

Since probiotics are live microorganisms, keeping them alive and stable is necessary but could be a challenge.

Also, the risk of infection increases since your body is dealing with live bacteria. 

Postbiotics, on the other hand, are easier to formulate and store and have a longer shelf-life.

Postbiotics are usually well-tolerated.

You won't run the risk of developing an infection or allergy

Can You Take Probiotics And Postbiotics Together?

You can take probiotics along with postbiotics for maximum health benefits.

Your gut bacteria's stability depends on age, diet, and environmental factors.

Taking them together will help maintain a balance in your gut microbiome.  

How Do Postbiotics Work?

Scientists have yet to fully understand how postbiotics work.

However, butyric acid, a well-known postbiotic product, might help us understand it better.

Bacteria use butyric acid, a short-chain fatty acid, as fuel.

It can alter the levels of certain bacteria in your colon.

Your colon has the highest levels of bacteria compared to anywhere else in the body.

It's important to regulate them to support your immune system.

Scientists have found that you can manipulate bacterial presence in your colon by increasing butyric acid levels. 

That's an example of the effects that postbiotics have on our gut.

What Are The Benefits Of Postbiotics?

Some research has shown that postbiotics can improve digestive health and support the immune system. 

Some additional benefits of postbiotics include:

Infographic showing the different benefits of postbiotics

Do Postbiotics Help You Lose Weight?

Despite limited research, some studies have shown that postbiotics might aid weight loss.

Postbiotics like short-chain fatty acids can suppress hunger signals, thus aiding in weight loss.

How To Naturally Boost Postbiotics?

You can naturally boost postbiotic levels in your body by eating probiotic and prebiotic-rich foods

When your gut bacteria get more fiber to feed on, they naturally produce more postbiotics. 

Some prebiotic-rich foods are oats, barley, chia seeds, flaxseeds, onions, and garlic.

Fermented foods like kimchi, yogurt, kefir, tempeh, miso, and sourdough bread also help boost gut bacteria.

The gut bacteria, in turn, increase postbiotics in the body. 



Postbiotics Supplements: How They Work

Postbiotic supplements contain a concentrated dose of short-chain fatty acids, peptides, or enzymes.

They act as food for your gut bacteria and help them thrive.

They can also influence your immune system, regulate inflammatory response, and boost overall immunity.  

Who Needs Postbiotics Supplements?

Taking postbiotic supplements could be beneficial if you're targeting specific health concerns.

Supplements are a simple and reliable way to ensure you get your required dose. 

Always consult your doctor before starting any supplements.   

Potential Downsides Of Postbiotics

Most postbiotic supplements are safe. 

However, you should still be careful and regularly consult your healthcare provider.

Research around postbiotic supplements is still in the initial stages.

Thus, when buying a supplement, ensure they are from a reputable brand and the health claims are backed by research.

You might be at a risk of developing an adverse reaction to a postbiotic supplement if:

Summary

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027423

https://www.nature.com/articles/s41575-021-00440-6

https://www.nature.com/articles/d42473-020-00552-8

https://pubmed.ncbi.nlm.nih.gov/32024037

https://www.healthline.com/nutrition/postbiotics

Magical black powder or just a placebo effect? Activated charcoal is a new-fangled treatment that claims to alleviate stomach bugs. Its popularity is exploding as a potential fix for various health issues. Since there's a lot of misinformation on the benefits of activated charcoal, it's essential to stay informed on its mode of action and make sense of all the data available on its efficacy. Read on to understand the usage, benefits, and risks of using activated charcoal for stomach bugs.

What Are Stomach Bugs?

Stomach bugs, known as viral gastroenteritis, are intestinal infections that cause watery diarrhea, abdominal cramps, nausea, vomiting, and sometimes fever. 

While generally not severe in healthy individuals, they can pose risks to infants, older adults, and those with compromised immune systems.

How Do Stomach Bugs Spread?

Now, let's talk about the causes of stomach bugs. The primary transmission routes for stomach bugs are:

Additionally, viruses can trigger stomach bugs.

Some countries, including the United States, offer vaccines to prevent viral gastroenteritis infections.

How Can You Prevent Stomach Bugs?

Since there's no specific cure for stomach bugs, prevention is crucial. Key preventive measures include:

Activated Charcoal For Stomach Bug: How It Works

Activated charcoal functions through a process known as adsorption

It attracts and binds substances in your digestive tract, preventing them from being absorbed. 

This property makes it useful in medical emergencies, such as accidental poisoning, where medical professionals use it to trap excess drugs and mitigate potential toxicity.

However, activated charcoal's role is less evident in the context of stomach bugs. 

While it may bind excess fluids and potentially alleviate diarrhea symptoms by hardening stools, it does not address the underlying cause.

Activated charcoal cannot eliminate the viruses, bacteria, or parasites that typically cause stomach bugs.

Diagram showing the process of toxin adsorption by activated charcoal

Does Activated Charcoal Help Prevent Stomach Bugs?

Activated charcoal is not a treatment or preventative strategy for stomach bugs. 

Activated charcoal can adsorb toxins, but viruses, bacteria, or parasites cause the disease.

While some limited evidence shows that charcoal may help with diarrhea, a frequent symptom of stomach infections, its overall effectiveness remains to be determined. 

Some studies suggest using it to control diarrhea in palliative care, but its benefits need further research.

Most stomach bugs disappear on their own within a few days

Relaxation and enough water intake are the most effective strategies for acquiring fluids and electrolytes lost due to vomiting or diarrhea.

Can You Take Activated Charcoal For A Stomach Virus?

Doctors don't recommend activated charcoal to treat a stomach virus. 

This condition does not respond to activated charcoal because it lacks antiviral, antibacterial, or antiparasitic properties.

Scientific evidence supporting its effectiveness against the stomach virus is limited. 

Therefore, it's generally advised not to use activated charcoal for stomach viruses.

Does Activated Charcoal Help With Gut Bacteria?

Activated charcoal can help with gut bacteria, particularly in cases of diarrhea resulting from bacterial infections. 

A 2017 study highlights activated charcoal's ability to attract and expel ingested toxins from the gastrointestinal tract, like harmful bacteria whose toxins cause diarrhea. 

Activated charcoal adsorbs these substances on its surface and prevents them from being absorbed into the body, thus helping to manage diarrhea symptoms. 

However, while it shows promise, more research is required to fully understand its effectiveness and potential benefits in managing gut bacteria-related conditions.

How Much Activated Charcoal Should I Take for a Stomach Bug?

Age GroupDosage (grams)
Children <1 year10g to 25g
Children 1 - 12 years25g to 50g
Teenagers and Adults25g to 100g


Are There Any Risks In Taking Activated Charcoal For Stomach Bugs?

Yes, there are risks with taking activated charcoal for stomach bugs. 

Inhaling charcoal can cause side effects like vomiting, bowel blockages, and aspiration pneumonitis

Aspiration pneumonitis is a severe lung problem that can make breathing hard.

People at higher risk for these side effects include those who:

Giving activated charcoal to an unconscious person is also risky.

It can cause vomiting, which could lead to choking. 

If someone with vomiting and diarrhea becomes unconscious, it is a medical emergency.

So, while activated charcoal can help with stomach bugs, it's essential to talk to a doctor first to avoid these risks.

Who Should Not Consume Activated Charcoal

Activated charcoal is not suitable for everyone. 

Doctors advise against using activated charcoal for patients with an unprotected airway, particularly those who are barely conscious. 

It could cause severe breathing problems or even death from accidental inhalation (aspiration).

Here are the conditions under which you should avoid activated charcoal:

It's best to have your doctor monitor you in these conditions.



Usage Guide For Activated Charcoal

Activated charcoal can be helpful in certain situations, but using it safely and correctly is crucial.

Here are some precautions to keep in mind when using activated charcoal:

Call poison control or a healthcare professional immediately if poisoning occurs. 

For treating poisoning, the recommended dosage is:

For multiple doses, after the initial dose, the recommended amounts are:

Always seek professional advice before using activated charcoal.

Summary: Can Activated Charcoal Help Stomach Bugs?

References

https://www.mayoclinic.org/diseases-conditions/viral-gastroenteritis/symptoms-causes/syc-20378847

https://www.webmd.com/vitamins-and-supplements/activated-charcoal-uses-risks

https://www.medicalnewstoday.com/articles/activated-charcoal-for-a-stomach-bug

https://pubmed.ncbi.nlm.nih.gov/29231746

https://www.niddk.nih.gov/health-information/digestive-diseases/viral-gastroenteritis/treatment

https://www.healthline.com/health/activated-charcoal-gastroenteritis

https://www.tandfonline.com/doi/full/10.1080/03007995.2017.1416345

https://www.mayoclinic.org/drugs-supplements/charcoal-activated-oral-route/proper-use/drg-20070087

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Do you have your 23andMe DNA data?

Learn about your MTHFR gene status for free!


Have you taken an ancestry test with 23andMe, AncestryDNA, or other companies? Then, you're already on the path to unlocking the incredible insights within your raw DNA data. This article delves into the world of DNA raw data analysis, guiding you through the tools to help decode the secrets hidden within your genes. Are you ready to discover the best platform to upload raw DNA data? Join us as we explore the top 10 tools that can help you get the best out of your raw DNA!

What Is A Raw DNA Data?

Your DNA is a complex instruction manual written using only four letters: A, T, G, and C.

Each human has a unique manual of their own. 

These manuals are 99.99% similar across humans, but the 0.01% can make a big difference.

For instance, some people could have an A in a spot where a C should be instead.

A raw data file from companies like 23andMe or AncestryDNA digitally tabulates these differences, which are called single-nucleotide polymorphisms (SNPs).

Here’s a small example of what data might look like in a raw DNA file:

SNPChromosomePositionGenotype
rs123456112345678AT
rs7891012910112132GT
rs445566398765432CG

What Does An SNP Signify?

Raw data contains a list of variant loci on your DNA called SNPs. Scientists and researchers can use this raw data to study and learn more about genetics, human ancestry, and even some health conditions. 

They can compare your genetic markers with those of others to find patterns and make connections.

Genetic Diversity

SNPs are little tweaks to your DNA that make you unique. While 99.99% of your DNA is the same as everyone else’s, it’s that 0.01% that makes all the difference.

Ancestry and Heritage

SNPs can also tell you about your ancestral roots. They help trace where your ancestors came from and how they migrated for thousands of years. That’s how companies like 23andMe can tell you you’re 30% Irish or 10% Native American.

Health Insights

Certain SNPs have links to health conditions. For instance, a specific SNP could increase your risk for conditions like heart disease, diabetes, or certain cancers. An awareness of your risk for health conditions can help you take the necessary preventive measures or get screened early.

Fitness and Nutrition

Your SNPs can offer insights into how your body responds to different exercise plans or diets. You can optimize your workout routine and nutrition plan based on what works best for your genetic profile.

It’s important to remember that raw DNA data is a blueprint of your genetic information.

It can reveal sensitive personal details, and you should handle it carefully.

Only share it with trusted sites that maintain your privacy and data security.

We’re here to help you with just that!

Screenshot of Genotyping DNA Raw Data File

How Is Ancestry Information Obtained From DNA?

The DNA data file from genealogical tests has information on around 700,000 SNPs in your DNA. 

The portions of DNA close to each other (markers) are often passed down together. 

Genetic ancestry tests use these markers to track your lineage and report ancestry and ethnicity.

They compare your DNA data with that of millions of other people and find regions of similarity.

The more the similarity, the more closely you are related to that person.

However, this information is only a drop of water compared to the ocean of information you can get from your DNA raw data file.

There are many third-party tools and DNA upload sites that interpret your DNA raw data for you. 

Some of the well-known DNA raw data analysis tools are Xcode Life, Genome, Stratagene, and GEDMatch.

Note: Most of these companies accept only genotyping raw data (like the ones from 23andMe and AncestryDNA).

What Else Can Your DNA Raw Data Tell You?

Analyzing your DNA raw data can tell you much about your health and wellness.

You can get insights into your:

Learning so much about yourself has never been this simple.


  1. Family Tree DNA (FTDNA)
  2. AncestryDNA
  3. 23andMe
  4. MyHeritage DNA

DNA Raw Data Analysis: 13 Best Tools (Some Are FREE!)

Many third-party companies allow you to upload your DNA raw data to provide easy-to-understand genetic reports on health and wellness.

ToolPriceCategories covered
Xcode Life
- the highest number of reports
- 3000+ markers analyzed
- 750 + traits covered
Starting at $30
(Free reports available with pack products)
Nutrition
Fitness
Allergy
Skin
Health
Sleep
Personality
BRCA and Breast Cancer
MTHFR and Methylation
Personalized Medicine
Caffeine (free)
Promethease$12Basic health and reports
Genetic GenieFree; Option for voluntary donation starting from $5.Only methylation and detox analysis
GEDMatch3 free tools, 45+ premium tools.
Ancestry.
Mainly for family matches using combined 23andMe, Ancestry DNA, Family Tree DNA databases.
GenomelinkFree (~100 traits); $14 monthly subscription for 312 traitsNutrition, personality, intelligence, physical, and sports traits
SelfDecode1 free report; $278-$695 and $99 annual memebership feeNutrition, fitness, and health
MyTrue AncestryBasic version is free.; Membership costs up to $596Ancestry reports only
Genomapp3 reports are free; Other reports cost up to $25Health conditions and precision medicine
Livewello1 free trait; Up to $25/month subscriptionNutrition and Precision Medicine
Strategene$95, only one reportMetabolic pathway information
Enlis Genomics1 free report; Other reports up to $80Scientific health reports only
Nutrahacker1 free report, other reports up to $145Genetic traits, nutrition, metabolism, fitness, lactation etc
DNAFit/Circle DNA5 bundle reports ($379)Fitness, medicine, skin, mental health, maternal health etc

Happy choosing!

Xcode Life

Xcode Life is a global genetics and bioinformatics company that analyzes raw DNA data files from companies like 23andMe, AncestryDNA, FTDNA, MyHeritage, and LivingDNA.

Xcode provides a variety of expertly curated reports, starting at just $20.

Xcode Life Reports List

  1. Nutrition report
  2. Fitness report
  3. Health report
  4. Allergy report
  5. Skin report
  6. Breast Cancer and BRCA report
  7. Methylation and MTHFR report
  8. Personalized Medicine report
  9. Gene Sleep Report
  10. Traits and Personality report
  11. Caffeine report (free with Pack Products)

The reports contain specific, helpful recommendations for people with the same genetic type.

They are delivered within 24 hours.

Report interpretation assistance is also available upon request.

Xcode provides bundle options, consolidating over 1000 traits into a single analysis report.

Professional practitioners such as physicians, surgeons, nutritionists, sports trainers, chiropractors, and more use Xcode for their raw DNA data analysis needs.

Get your 23andMe raw data analyzed here.

Promethease - Now acquired by MyHeritage - Latest Updates

Promethease is a software program that was developed by SNPedia to perform raw data analysis.

It uses your 23andMe raw data to generate disease-based reports.

How Much Does Promethease Cost?

They charge $12 per report.

It’s important to note that Promethease reports may be overly technical for most users, who usually don’t have expert knowledge of polymorphisms and biostatistics.

The system is based on literature search and retrieval.

It builds a report based on the SNPedia database against the raw DNA data from sites like AncestryDNA, 23AndMe, or FamilyTreeDNA.

The reports primarily contain information about health and precision medicine.

For instance, the report can mention your genetic risk for diseases like Alzheimer’s.

Though it is a popular service, its scientific integrity is often questioned due to its reliance on SNPedia, an open-source service.

Update: In 2019, MyHeritage acquired Promethease and SNPedia.

Promethease was originally offered free of charge. However, MyHeritage acquired the DNA analysis service in 2019.

They maintain SNPedia as a free resource for academic and non-profit users.

Non-European users’ DNA raw data was shifted into new accounts on MyHeritage.

Users retain ownership of their DNA raw data file and may delete their data from MyHeritage’s server at their discretion. 

GeneticGenie Methylation and Detox Analysis

Genetic Genie provides free methylation and detox reports.

This tool uses your DNA raw data from companies like 23andMe and AncestryDNA to perform methylation analysis.  

The site also provides a tool for a detox analysis that looks for defects in the cytochrome P450 detox enzymes.  

Genetic Genie Methylation

Incorrect methylation leads to a wide range of serious medical conditions.

This makes the methylation profile offered by Genetic Genie a good report.

The following genes are included in Genetic Genie’s Methylation panel:

  1. COMT
  2. MTHFR
  3. VDR
  4. MTR
  5. MTRR
  6. BHMT
  7. SHMT
  8. CBS

14 markers in these genes are reported in the panel.

Genetic Genie Detox

The detox profile looks at single nucleotide polymorphisms (SNPs) in genes that affect the detoxification pathway of the body.

The following genes are included in Genetic Genie’s Detox panel:

  1. CYP1A1
  2. CYP1A2
  3. CYP1B1
  4. CYP2C9
  5. CYP2E1
  6. CYP3A4
  7. GSTP1
  8. SOD2
  9. NAT1
  10. NAT2

22 markers in these genes are reported in the panel.

This is a free service, but a voluntary donation starting from $5 is accepted.



GEDMatch

GEDMatch is a platform that helps understand your lineage via raw DNA files from genealogy companies.

The service is free, but the user experience can seem challenging for users who need to be used to exploring genetic data to understand the reports.

GEDmatch provides a range of complimentary tools and a selection of more advanced features that require a paid subscription. 

GEDmatch.com Login

You can log in to your GEDmatch account in 4 simple steps:

  1. Go to www.gedmatch.com and click the ‘Login’ button in the top right corner.
  2. Enter the email ID that you used to register your account
  3. Key in your password
  4. Click on the ‘Login’ button

If you forgot your password, you can reset it with this link

Once you create your account, you can upload your raw DNA data here.

On the upload page, you’ll need to enter the following details:

  1. Donor information
  2. Details of raw data
  3. Privacy information

Once the upload is successful, you should be assigned a kit number.

GEDmatch Genesis Free Tools

GEDmatch provides three free tools:

  1. One-to-many DNA comparison against GEDmatch users
  2. One-to-one DNA comparison with a close relative 
  3. Admixture to determine ethnic ancestry

Purchasing a Tier 1 membership at $10 per month unlocks access to:

  1. Segment search to find your most recent common ancestors
  2. Enhanced one-to-one comparison to examine the quality of the results
  3. Clustering of matches to determine recent common ancestors

GEDmatch Review

Various online genealogy groups recommend the GEDmatch tool. 

Interestingly, GEDmatch helped law enforcement to arrest the Golden State Killer, responsible for more than 50 rapes and at least 13 murders in the 1970s and 80s.

Ever since then, GEDmatch has gained popularity as a crime-solving tool.

Read an in-depth review of GEDMatch here.

Genomelink lets users upload raw DNA data from 23andMe, Ancestry, or MyHeritage. 

The site can also connect directly to their accounts on these websites to retrieve their DNA data. 

Users who upload DNA data will receive a free report on 100 traits immediately.

However, to unlock more traits, you’ll need a subscription to their website for $14/month, which may not be cost-effective.

If you sign up, all your reports will be consolidated and presented in your dashboard, which you can only access online.

It’s important to note that downloadable PDF reports are unavailable from Genomelink.

A feedback option near each trait can help you review how accurate the trait results are.

Overall, they provide over 352 traits across 20 reports. 

Most of these reports are genealogical and focused on revealing ancestry.

Their website does not advertise bundled reports anymore. 

The actual prices of each report remain concealed until a user creates an account with Genomelink.

Genomelink Login

Follow these steps to log in to your Genomelink account:

  1. On the website homepage, click the “Sign In” button in the top right corner.
  2. Enter the email address that you used to register your account.
  3. Key in your password and click on the “LOG IN” button.

Genomelink Dashboard Of A Free Account

Genomelink Reviews

Genomelink can be a good, cost-free place to start if you are new to genetic tests. 

The results are moderately user-friendly and readable. 

They seem to have in-depth information on privacy and the use of users’ data. 

The free version of Genomelink is worth a try. 

However, think twice before purchasing a subscription.

The primary benefit of the subscription is that Genomelink emails you one trait result each week. 

The report bundles are overpriced for the number of traits they cover. 

Although the sample reports look visually appealing, the web-based reports could tell a different story.




SelfDecode

SelfDecode offers personalized DNA testing and provides health and wellness reports by analyzing your genetic data. 

It also offers genome analysis with a personalized genetics blog that helps you understand your DNA results.

Once you create a SelfDecode account, you can upload your raw DNA data.

A free report for a few traits is generated within a couple of hours.

SelfDecode Membership Plans

The annual membership subscription fee for SelfDecode is $99.

Depending on the services you’re interested in and whether or not you already have a raw DNA file, the total upfront payment can range from $298 to $695. 

After that, you will be billed a $99 fee annually.



Livewello Raw Data Analysis

Livewello accepts raw data files from 23andMe, AncestryDNA, Family Tree DNA, and Gene By Gene.

It offers 15 genetic reports and 160 health reports. However, the range of these reports is much smaller, with only a few SNPs studied per report.

Some of the reports include:

You can create an account for free, but reports require a membership.

Livewello’s payment plans range from $6.95 to $25 monthly or $75 to $215 yearly, with progressively better amenities.

A DNA kit may be purchased for $165 if required.

Livewello offers 20 reports. Some of them include:

The New StrateGene Analysis: 2025 Update

StrateGene initially offered a $295 DNA kit as the only sample collection model.

Now, they have switched to a virtual DNA data upload model.

You can upload your DNA raw data files from 23andMe to StrateGene. 

They offer one report, priced at $95, with information on nine essential processes in your body, including pathways for:

Users find the reports too complex to be of actual use. 

Strategene may not be the best choice for those who prefer easily understandable results and readily implementable recommendations.

Enlis Genomics 23andMe Raw Data Analysis

This 23andMe raw data analysis service provider is more for educational than direct consumer purposes.

Their service caters to research scientists. 

They analyze DNA data to find health risks associated with specific genetic variants.

The initial intention of developing this software is to allow researchers to analyze whole genome files. 

They have also added a software program for personal use and a free genome report accessible directly from their site.

While the service is free, understanding and interpreting the report takes a reasonable amount of scientific knowledge.

NutraHacker Raw Data Analysis: 2025 Update

Nutrahacker accepts raw DNA data from 23andMe, AncestryDNA, tellmeGen, or MyHeritage.

Upon registering with your details and uploading your raw DNA data, you can access a ‘Genotype Imputation’ report for free.

NutraHacker offers eight other genetic reports, including:

They advertise two bundle packs, a Detox and PharmaShield panel($300/year) and the WGS Critical Genetics panel ($395 one-time).

DNAFit Raw Data Analysis: 2025 Update

DNAFit now redirects to CircleDNA. They offer five categories of analyses, including:

Each of these reports costs $379 and includes collection kits.

A children’s DNA kit is available for $299 as well.

The report is available online. 

Initially, the information feels overwhelming.

However, the reports do have reasonably relevant background information.

The reports comprehensively include a list of the genes analyzed in the test and information about each gene.

If you are a hardcore athlete, consider CircleDNA.

Before you buy, check out our comparative blog on the top 5 DNA fitness report providers.

According to DNA Testing Choice, a popular genetic testing company review website, their privacy policy contains clauses regarding how DNAFit could pass on user data to third parties for research with or without client consent.

Lifenome Raw Data Analysis

Lifenome accepts DNA raw data files from 23andMe, AncestryDNA, and FamilyTreeDNA. 

They offer reports on the following traits:

The reports are comprehensive and easy to understand, with clear implications and recommendations.

The site does not clearly indicate pricing or how to purchase these reports, which could deter some users from using Lifenome’s services.

Our Top 3 Picks For Raw DNA Data Analysis In 2025

1. Xcode Life

With the most reports and over 750 traits analyzed rapidly, Xcode Life is undoubtedly the best raw DNA data analysis tool in 2024.

Additionally, its website is user-friendly and compatible with 10+ DNA testing companies, including 23andMe, AncestryDNA, and FTDNA.

Xcode provides comprehensive, jargon-free, and interactive reports starting at just $20 with clear recommendations and information on each trait marker analyzed.

GenomeLink has a user-friendly website with different products that users can apply to all walks of life.

They provide a free report with over 100 traits upon account creation.

While the reports appear lucrative, it’s important to note that the rest of their reports and traits are accessible only through a $14/month subscription. Additionally, the value of their report bundles does not match their cost.

Despite this, their reports can help users understand their ancestry, curate their diets, and improve their workouts for a healthier lifestyle. 

3. SelfDecode

SelfDecode offers whole genome analysis, generating readable reports within a few hours.

It also offers free trait reports for a handful of markers upon account creation.

The comprehensive nature of these reports can significantly improve consumers’ knowledge of their disease risk and behavioral patterns.

Users thus remain informed and prepared on their genetic makeup.

FAQs On Raw DNA Data Analysis

How To Analyze Raw DNA Data?

Several genetic testing companies offer services to analyze raw DNA data and provide helpful insights about health and wellness.

Xcode Life stands out due to its affordable, comprehensive, and user-friendly genetic reports that are delivered within 24 hours.

How To Interpret Raw Data?

Your raw data likely contains the following columns: RSID, chromosome, position, and genotype. 

Each row analyzes the genotype of an SNP (single nucleotide polymorphism), or a mutation in your DNA, at a certain position on a specific chromosome.

Genetic testing companies like Xcode Life can decode your raw data to give you valuable information about your health and wellness for as little as $30.

Is There A Free Raw DNA Analysis For Health?

While some companies may offer a couple of health-related reports for free, getting a comprehensive health report from your raw DNA can give you a clear picture of your overall wellness and possible risks.

Xcode Life offers a comprehensive Gene Health report that studies your risk for over 45 chronic conditions for just $50.

How Much Does A DNA Analysis Cost?

While most genetic testing companies charge over $100 for their DNA analysis services, Xcode Life offers individual reports priced between $30 and $50, with comprehensive report bundles priced between $160 and $199.

Anti-inflammatory Diet: An Overview

Inflammation is not an enemy in typical cases. When your immune system identifies something as foreign, it triggers an inflammatory response, protecting your body against viruses and other pathogens.

However, in some cases, the inflammation continues to persist even if there's no foreign invader.

This is where inflammation is the enemy, as it can increase your risk for conditions like:

An anti-inflammatory diet focuses on consuming foods that help naturally reduce inflammation in the body while avoiding foods that can trigger or worsen inflammation.

If you have a health condition that causes chronic inflammation, consuming an anti-inflammatory diet may alleviate your symptoms.

While the anti-inflammatory diet is safe, you must consult your doctor before starting it.

Who’s It For?

An anti-inflammatory diet benefits people with conditions that are caused by or worsen due to chronic inflammation. Some of these include:

Some research also states that eating an anti-inflammatory diet may reduce the risk of cancer.

What Are The Benefits?



Types Of Anti-inflammatory Diet (Food List PDF Below)

There are different types of anti-inflammatory diets, depending on the foods they recommend. Let’s take a brief look at the three most popular ones!

Mediterranean Diet

This diet focuses on the consumption of:

It recommends avoiding the following foods:

DASH Diet

DASH, or the Dietary Approaches to Stop Hypertension, is similar to the Mediterranean diet, which focuses on consuming less or no salt and includes more low-fat dairy products. 

MIND Diet

This diet combines a few parts of the Mediterranean diet with the DASH diet and is considered healthy for the brain.

It may guard against Alzheimer’s disease and other forms of dementia.

The MIND diet recommends the consumption of:

Like other anti-inflammatory diets, the MIND Diet advises limiting the following foods:

Components Of Anti-inflammatory Food List + PDF

Foods to IncreaseFoods to Decrease
Fruits and Vegetables
- Berries, cherries, peppers
- Sweet potato, pineapple, yellow bell pepper, squash, peaches
- Dark leafy greens, Brussels sprouts, cabbage, green beans
- Blueberries, blackberries, grapes, eggplant, olives, plums, purple cabbage
Proteins
- Grain-fed beef
- Processed meats
Fiber
- Whole grains
- Bran cereal
- Nuts
- Brown rice
- Potato
Trans-fats
- Partially hydrogenated oils
- Baked goods
- Fried foods
Proteins
- Plant-based proteins (found in beans, legumes, nuts and seeds)
- Grass-fed meat and fish
Saturated fats
- Meats like lamb, pork, fatty beef, chicken with skin
- Dairy products
- Fruit juices
Herbs & Spices
- Ginger
- Turmeric
- Sage
- Cumin
- Cloves
- Cinnamon
- Paprika
- Tarragon
Omega-3’s
- Fatty fish
- Fish oil
- Whole grains
- Walnuts
*Eat more omega-3 fatty acids than omega-6 fatty acids.
Monounsaturated Fatty Acids
- Olive oil
- Avocados
Desserts/Snacks
Dark chocolate containing 70% or more cocoa

Download PDF

Who Should Avoid An Anti-inflammatory Diet?

FAQs About Anti-inflammatory Diet

What Is The Number One Food That Kills Inflammation?

Oily or fatty fish, like sardines, salmon, trout, and herring, are rich in omega-3 fatty acids. 

These fatty acids have been associated with a reduction in C-reactive protein, a key inflammation marker.

What Can I Drink To Reduce Inflammation?

Several beverages and drinks can help reduce inflammation. Some of these include:

What Is The Strongest Natural Anti-Inflammatory?

Omega-3 fatty acids are the most potent natural anti-inflammatory. 

They are found abundantly in the following foods:



How Long Does It Take To Reduce Inflammation Through Diet?

An anti-inflammatory diet may take a few weeks to become effective. 

We must remember that an anti-inflammatory diet is not a magic pill; it can take longer than six or seven weeks to show effects.

What Foods To Avoid On An Anti-inflammatory Diet?

If you are on an anti-inflammatory diet, you must limit or avoid the consumption of the following foods:

Summary: Anti-inflammatory Diet + Food List PDF

  1. An anti-inflammatory diet involves consuming foods that naturally fight inflammation and avoiding foods that trigger inflammation.
  2. The primary benefit of an anti-inflammatory diet is that it reduces the body's inflammation, a major causative and aggravating factor for many chronic diseases.
  3. The three commonly followed anti-inflammatory diets are the Mediterranean diet, the DASH diet, and the MIND diet.
  4. Anti-inflammatory diet is not a weight loss plan and should not be used by anyone who wishes to lose weight.
  5. Oily or fatty fish rich in omega-3 fatty acids are the best food that kills inflammation.
  6. On an anti-inflammatory diet, you must avoid processed foods, foods with added sugar or salt, fried and fatty foods, and processed meat.


References

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